Clinical Lipidology: A Companion to Braunwald's Heart Disease E-Book

dr. Ballantyne—one Of The Foremost Lipid Experts In The World And Recruited By Dr. Braunwald’s Heart Disease Editorial Team—together With A Stellar Cast Of Contributors Provides All Of The Scientific And Clinical Information You Need To Effectively Manage Every Aspect Of Dyslipidemia. From Basic Science To Pathogenesis Of Atherothrombotic Disease To Risk Assessment And The Latest Therapy Options, This New Title In The Braunwald’s Heart Disease Family Offers Unparalleled Up-to-date Coverage And Expert Guidance On Lipidology In A Straightforward, Accessible, And User-friendly Style. Plus, Expert Consult Functionality Gives You Anytime, Anywhere Access To The Full Text Online. • Includes Full Text Online Access At Expertconsult.com. • Features The Expertise Of One Of The Foremost Experts In The Field, Ensuring You Get Authoritative Guidance With The Most Definitive Knowledge Available. • Contains Extensive Clinically Relevant Information Covering Risk Assessment, Therapy, Special Patient Populations, And Experimental Therapies, Including Targeting Hdl To Help You Effectively Manage Any Challenges You Face. • Uses Treatment Algorithms For Easy Access To Key Content. • Presents Current Practice Guidelines That Assist In The Decision-making Process. doody Review Services reviewer: james M Schipper, Md(ochsner Clinic Foundation) description: this Is An Overview Of Contemporary Thought On The Pathophysiology, Assessment, And Treatment Of Lipid Disorders. purpose: cardiovascular Disease Is A Leading Cause Of Death In Industrialized Nations And A Major Healthcare Concern. Fortunately, With Early Diagnosis And Treatment, Many Of These Deaths Are Preventable. This Book Seeks To Motivate Practitioners To Improve Their Care Of Their Hyperlipidemic Patients. audience: this Book Is Directed At Medical Students, Midlevel Providers, Physicians In Training, And Practicing Clinicians Who Require A Thorough Understanding Of Dyslipidemia. features: a Discussion Of Basic Lipid Metabolism And The Pathophysiology Of Plaque Formation Begins The Book. Screening And Risk Assessment Are Covered, Though The Focus Is On Laboratory Evaluation As Opposed To Stress Testing. Noninvasive Treatment, Both Lifestyle-based And Pharmacologic, Comprises The Largest Portion Of The Book. Several Sections Are Dedicated To Special Populations, Including Patients With Familial Disorders Or Diabetes, Women, Cardiac Transplant Recipients, And Others. Numerous, High Quality Diagrams And Tables Improve Understanding And Aid In Location Of Information. The Book Is Well Referenced And Indexed. assessment: this Book Upholds The High Standards That Would Be Expected Of A Companion To braunwald's Heart Disease . It Is Easy To Read, Yet Provides An In-depth Understanding Of Lipid Disorders. It Would Be A Welcome Addition To The Library Of Anyone Focused On Preventive Medicine And The Treatment Of Patients With Dyslipidemia. Cover......Page 1 Acknowledgments......Page 3 Contributing Authors......Page 4 Foreword......Page 7 Preface......Page 8 1. Human Plasma Lipoprotein Metabolism......Page 9 2. Regulation and Clearance of Apolipoprotein B–Containing Lipoproteins......Page 19 3. Absorption and Excretion of Cholesterol and Other Sterols......Page 34 4. High-Density Lipoprotein Metabolism......Page 53 5. Lipoproteins: Mechanisms for Atherogenesis and Progression of Atherothrombotic Disease......Page 64 6. Genetic Dyslipidemia......Page 79 7. High-Density Lipoprotein Mutations......Page 93 8. Lipoprotein Oxidation and Modifi cation......Page 101 9. Cholesterol: Concentration, Ratio, and Particle Number......Page 119 10. High-Density Lipoprotein Cholesterol in Coronary Heart Disease Risk Assessment......Page 127 11. Lipoprotein(a)......Page 138 12. Clinical Evaluation for Genetic and Secondary Causes of Dyslipidemia......Page 152 13. Use of High-Sensitivity C-Reactive Protein for Risk Assessment......Page 166 14. Role of Lipoprotein-Associated Phospholipase A2 in Vascular Disease......Page 175 15. Emerging Assays......Page 186 16. Noninvasive Assessments of Atherosclerosis for Risk Stratifi cation......Page 192 17. Overview of General Approach to Management of Elevated Low-Density Lipoprotein Cholesterol and Mixed Dyslipidemia, High Triglycerides, and Low High-Density Lipoprotein Cholesterol......Page 207 18. Treatment Guidelines Overview......Page 210 19. Dietary Patterns for the Prevention and Treatment of Cardiovascular Disease......Page 225 20. Exercise and Lipids......Page 240 21. Weight Loss......Page 248 22. Statins......Page 261 23. Bile Acid Sequestrants......Page 289 24. Cholesterol Absorption Inhibitors......Page 296 25. Nicotinic Acid......Page 306 26. Fibrates......Page 323 27. Omega-3 Fatty Acids......Page 334 28. Endocannabinoid Receptor Blockers......Page 347 29. Combination Therapy for Dyslipidemia......Page 360 30. Low-Density Lipoprotein Apheresis......Page 371 31. Nutriceuticals and Functional Foods for Cholesterol Reduction......Page 384 32. Evolving Targets of Therapy......Page 395 33. Modulation of Biomarkers of Inflammation......Page 404 34. Invasive Imaging Modalities and Atherosclerosis: The Role of Intravascular Ultrasound......Page 418 35. Noninvasive Imaging Modalities and Atherosclerosis: The Role of Ultrasound......Page 428 36. Noninvasive Imaging Modalities and Atherosclerosis: The Role of Magnetic Resonance Imaging and Positron Emission Tomography Imaging......Page 440 37. Special Patient Populations: Diabetes and Metabolic Syndrome......Page 451 38. Special Patient Populations: Women and Elderly......Page 471 39. Special Patient Populations: Acute Coronary Syndromes......Page 481 40. Special Patient Populations: Transplant Recipients......Page 494 41. Special Patient Populations: Chronic Renal Disease......Page 508 42. Special Patient Populations: Lipid Abnormalities in High-Risk Ethnic Groups......Page 517 43. Special Patient Populations: HIV Patients......Page 527 44. Investigational Agents Affecting Atherogenic Lipoproteins......Page 538 45. Therapeutic Targeting of High-Density Lipoprotein Metabolism......Page 552 Experimental Therapiesof the Vessel Wall......Page 561 Index......Page 576 Dr. Ballantyne- one of the foremost lipid experts in the world and recruited by Dr. Braunwald's Heart Disease editorial team- together with a stellar cast of contributors provides all of the scientific and clinical information you need to effectively manage every aspect of dyslipidemia. From basic science to pathogenesis of atherothrombotic disease to risk assessment and the latest therapy options, this new title in the Braunwald's Heart Disease family offers unparalleled up-to-date coverage and expert guidance on lipidology in a straightforward, accessible, and user-friendly style. Plus, Expert Consult functionality gives you anytime, anywhere access to the full text online. Includes full text online access at expertconsult.com. Features the expertise of one of the foremost experts in the field, ensuring you get authoritative guidance with the most definitive knowledge available. Contains extensive clinically relevant information covering risk assessment, therapy, special patient populations, and experimental therapies, including targeting HDL to help you effectively manage any challenges you face. Uses treatment algorithms for easy access to key content. Presents current practice guidelines that assist in the decision-making process. The author, one of the lipid experts in the world, together with a cast of contributors, provides all of the scientific and clinical information needed to manage every aspect of dyslipidemia. From basic science to pathogenesis of atherothrombotic disease to risk assessment and the latest therapy options, this new title in the Braunwald's Heart Disease family offers up-to-date coverage and guidance on lipidology in a straightforward, accessible, and user-friendly style. Contains extensive clinically relevant information covering risk assessment, therapy, special patient populations, and experimental therapies, including targeting HDL to help you effectively manage any challenges you face. Uses treatment algorithms for easy access to key content. Presents current practice guidelines that assist in the decision-making process