Clinical Functional MRI: Presurgical Functional Neuroimaging (Medical Radiology / Diagnostic Imaging)

Functional magnetic resonance imaging (fMRI) has contributed significantly to progress in neuroscience by permitting noninvasive imaging of the "human brain at work" under physiological conditions. Within clinical neuroimaging, fMRI is opening up a new diagnostic field by measuring and visualizing brain function. However, fMRI is not yet a standard diagnostic imaging procedure. This textbook is devoted to preoperative fMRI in patients with brain tumors and epilepsies, which are the most well-established clinical applications. By localizing and lateralizing specific brain functions in individual patients, as well as epileptogenic zones, fMRI facilitates the selection of a safe treatment and the planning and performance of function-preserving neurosurgery. State of the art fMRI procedures are presented, with detailed consideration of practical aspects, imaging and data processing, normal and pathological findings, and diagnostic possibilities and limitations. The relevant information on brain physiology, functional neuroanatomy, imaging technique, and methodology is provided by recognized experts in these fields. Further chapters address the validity of presurgical functional localization, multimodality functional neuroimaging, brain plasticity, and pitfalls, tips, and tricks. The book is designed to be of value to beginners, trained clinicians and experts alike. Functional magnetic resonance imaging (fMRI) permits noninvasive imaging of the "human brain at work" under physiological conditions. This is the first textbook on clinical fMRI. It is devoted to preoperative fMRI in patients with brain tumors and epilepsies, which are the most well-established clinical applications. By localizing and lateralizing specific brain functions, as well as epileptogenic zones, fMRI facilitates the selection of a safe treatment and the planning and performance of function-preserving neurosurgery. State of the art fMRI procedures are presented, with detailed consideration of the physiological and methodological background, imaging and data processing, normal and pathological findings, diagnostic possibilities and limitations, and other related techniques. All chapters are written by recognized experts in their fields, and the book is designed to be of value to beginners, trained clinicians and experts alike. Front Matter....Pages I-XI Introduction to Presurgical Functional MRI....Pages 1-7 Localization of Brain Activity using Functional Magnetic Resonance Imaging....Pages 9-51 Functional Neuroanatomy....Pages 53-85 Presurgical Functional MRI in Patients with Brain Tumors....Pages 87-134 Presurgical Functional MRI in Epilepsy....Pages 135-148 Functional Neuronavigation....Pages 149-166 Validity of Presurgical Functional Localization....Pages 167-187 Multimodality in Functional Neuroimaging....Pages 189-207 Brain Plasticity and fMRI....Pages 209-226 Clinical BOLD fMRI: Artifacts, Tips and Tricks....Pages 227-249 Back Matter....Pages 251-271 An overview of brain death, this book explores: the concept and historical approach of human death, clinical examinations of brain-dead patients, and ancillary tests in coma and brain death. It also covers bioethical discussions of brain death and its relationship with some consciousness disturbances, and the legal considerations of human death