Clinical Efficacy of Positron Emission Tomography : Proceedings of a Workshop Held in Cologne, FRG, Sponsored by the Commission of the European Communities As Advised by the Committee on Medical and Public Health Research

The series of workshops sponsored by the European Communities started with "Methodology of PET" at Hammersmith Hospital, London, in March 1984. This was followed by "Radiochemistry, Methodology and Standardization in PET" at the Service Hospitalier Frederic Joliot in Orsay, France, in March 1985. Both these meetings were, in the opinion of all participants, great successes, and it was agreed that such work­ shops should continue and be organized on the same basis. After these two workshops on the fundamentals of PET, time now is ripe to evaluate the clinical efficacy of PET investigations, and to discuss to what extend the information provided by this high technology and theoretical area has contributed to the understanding of disease mechanisms, leading to immediate clinical applications. As pointed out in the previous meetings, PET using short-lived radioisotopes produced in an on-line cyclotron is restricted to a few centers. Therefore, the topics studied so far were mainly of scientific interest and clinical problems were dealt with only marginally. Before this costly technique can be spread and new information made accessible to a broader clinical clientele, its clinical value must be demonstrat­ ed. So far, in the majority of studies, the central nervous system was the primary target organ, and PET has contributed a great deal to our understanding of brain physiology and pathology. Also on the heart, a substantial number of studies have been performed in various centers, but the application of PET to this organ is still somewhat limited. Front Matter....Pages I-XII Introduction....Pages 1-11 Front Matter....Pages 13-13 Ischemic Stroke Studied by 15 O-Labeled Compounds: Misery Perfusion and Luxury Perfusion....Pages 15-23 Ischemic Disease Studied with 15 O Labelled Compounds: Metabolic and Hemodynamic Disparities....Pages 25-36 Brain Glucose Metabolism and Blood Flow in Ischemic Stroke....Pages 37-53 Pet Studies in Internal Carotid Occlusion Patients: Base-Line Hemodynamic and Metabolic Alterations; Effects of Surgical Revascularization and Induced Arterial Hypertension....Pages 55-66 Functional Evaluation of Extra-Intracranial Arterial Bypasses Using Pet and Repeated Bolus Administration of 15 O Labeled Tracers....Pages 67-79 Positron Emission Tomography in Cerebrovascular Disorders: Results and Perspectives....Pages 81-89 Front Matter....Pages 91-91 Changes of Cerebral Glucose Metabolism in Movement Disorders....Pages 93-100 Progressive Supranuclear Palsy Studied by Pet....Pages 101-109 Central Dopaminergic Mechanisms in Monkey and Man Studied by Positron Emission Tomography....Pages 111-118 Application of Pet in Clinical Brain Research....Pages 119-122 SUMMARY of the Discussion on Brain I....Pages 123-124 Front Matter....Pages 125-125 Localizing Epileptic Foci by PET....Pages 127-136 Clinical Applications of PET: Studies of Brain Glucose Metabolism in Pediatric Neurology....Pages 137-147 The Value of PET in the Clinical Evaluation of Epileptic Patients....Pages 149-156 Front Matter....Pages 157-157 Energy Metabolism and Neurotransmitter Function in Ageing and the Dementias....Pages 159-174 PET in Dementia and Gliomas....Pages 175-191 Value of PET in the Clinical Evaluation of Dementias....Pages 193-200 Front Matter....Pages 201-201 Regional Brain Metabolism in Drugfree Schizophrenic Patients as Measured by Positron Emission Tomography....Pages 203-211 PET-Determination of Central D1- and D2-Dopamine Receptor Occupancy in Neuroleptic Treated Schizophrenics....Pages 213-219 Front Matter....Pages 201-201 Striatal Dopamine Receptors: Dose-Dependent Occupation by, and Rapid Washout of, Orally Given Neuroleptics in Humans....Pages 221-231 SUMMARY of Discussion on Brain II....Pages 233-236 Front Matter....Pages 237-237 Application of Positron Emission Tomography to the Study of Ischemic Heart Disease....Pages 239-241 PET in the Study of Angina Pectoris....Pages 243-251 Investigation of Myocardial Receptors by PET in Heart Diseases....Pages 253-263 Front Matter....Pages 265-265 Possible Clinical Efficacy of Positron Emission Tomography in Myocardial Infarction....Pages 267-272 The Role of PET in the Characterization of Myocardial Necrosis: Clinical Problems Related to the Non-Q-Wave Infarction....Pages 273-277 Investigation of Myocardial Viability After an Acute Myocardial Infarction Using Positron Emission Tomography....Pages 279-290 PET in the Evaluation of Myocardial Infarction....Pages 291-296 Application of PET to the Study of Heart Disease....Pages 297-298 SUMMARY of Discussion on Heart....Pages 299-302 Front Matter....Pages 303-303 Correlation of Structure and Function in Pulmonary Disease....Pages 305-313 Lung Edema: Clinical Efficacy of Positron Emission Tomography....Pages 315-328 Pharmacological Studies of the Lung with PET....Pages 329-334 Positron Emission Tomography of the Lungs....Pages 335-339 SUMMARY of Discussion on Lungs....Pages 341-342 Front Matter....Pages 343-343 Circulatory and Metabolic Studies in Extracranial Malignant Tumors....Pages 345-359 Some Biological Aspects of Soft Tissue Tumors as Studied by PET....Pages 361-370 Potential Clinical Value of PET in Oncology....Pages 371-376 Front Matter....Pages 377-377 Positron Emission Tomography with 11-C-Methionine in Brain Tumors: Methionine Kinetics, Tumor Delineation, and Follow-Up Studies After Therapy....Pages 379-390 Front Matter....Pages 377-377 Dopamine Receptors in Pituitary Adenomas and Effect of Bromocriptine Treatment — Evaluation with PET and MRI....Pages 391-400 Respondent to Brain Tumors: Interpretation of Tracer Uptake in Brain Tumors....Pages 401-412 SUMMARY of Discussion on Soft Tissue and Brain Tumors....Pages 413-414 Discussion of the Summaries of the Respondents....Pages 415-416 SUMMARY of Discussion on Strategy for the Future....Pages 417-417 Back Matter....Pages 419-421 The series of workshops sponsored by the European Communities started with "Methodology of PET" at Hammersmith Hospital, London, in March 1984. This was followed by "Radiochemistry, Methodology and Standardization in PET" at the Service Hospitalier Frederic Joliot in Orsay, France, in March 1985. Both these meetings were, in the opinion of all participants, great successes, and it was agreed that such workƯ shops should continue and be organized on the same basis. After these two workshops on the fundamentals of PET, time now is ripe to evaluate the clinical efficacy of PET investigations, and to discuss to what extend the information provided by this high technology and theoretical area has contributed to the understanding of disease mechanisms, leading to immediate clinical applications. As pointed out in the previous meetings, PET using short-lived radioisotopes produced in an on-line cyclotron is restricted to a few centers. Therefore, the topics studied so far were mainly of scientific interest and clinical problems were dealt with only marginally. Before this costly technique can be spread and new information made accessible to a broader clinical clientele, its clinical value must be demonstratƯ ed. So far, in the majority of studies, the central nervous system was the primary target organ, and PET has contributed a great deal to our understanding of brain physiology and pathology. Also on the heart, a substantial number of studies have been performed in various centers, but the application of PET to this organ is still somewhat limited Proceedings of a Workshop Held Oct. 23-25, 1986, in Cologne, FRG, Sponsored by the Commission of the European Communities as Advised by the Committee on Medical and Public Health Research