Clinical chemistry, immunology, and laboratory quality control : a comprehensive review for board preparation, certification, and clinical practice

## Notice No responsibility is assumed by the publisher for any injury and/or damage to persons, or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. Medicine is an ever-changing field. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administrations, and contraindications. It is the responsibility of the treating physician, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the publisher nor the authors assume any liability for any injury and/or damage to persons or property arising from this publication. Content: Front-matter , Pages i,iii Copyright , Page iv Dedication , Page v Preface , Pages xix-xx Chapter 1 - Instrumentation and Analytical Methods , Pages 1-18 Chapter 2 - Immunoassay Platform and Designs , Pages 19-34 Chapter 3 - Pre-Analytical Variables , Pages 35-45 Chapter 4 - Laboratory Statistics and Quality Control , Pages 47-66 Chapter 5 - Water, Homeostasis, Electrolytes, and Acid–Base Balance , Pages 67-84 Chapter 6 - Lipid Metabolism and Disorders , Pages 85-105 Chapter 7 - Carbohydrate Metabolism, Diabetes, and Hypoglycemia , Pages 107-126 Chapter 8 - Cardiac Markers , Pages 127-144 Chapter 9 - Endocrinology , Pages 145-175 Chapter 10 - Liver Diseases and Liver Function Tests , Pages 177-195 Chapter 11 - Renal Function Tests , Pages 197-212 Chapter 12 - Inborn Errors of Metabolism , Pages 213-228 Chapter 13 - Tumor Markers , Pages 229-247 Chapter 14 - Therapeutic Drug Monitoring , Pages 249-273 Chapter 15 - Interferences in Therapeutic Drug Monitoring , Pages 275-287 Chapter 16 - Drugs of Abuse Testing , Pages 289-306 Chapter 17 - Challenges in Drugs of Abuse Testing: Magic Mushrooms, Peyote Cactus, and Designer Drugs , Pages 307-316 Chapter 18 - Testing for Ethyl Alcohol (Alcohol) and Other Volatiles , Pages 317-335 Chapter 19 - Common Poisonings Including Heavy Metal Poisoning , Pages 337-351 Chapter 20 - Pharmacogenomics , Pages 353-362 Chapter 21 - Hemoglobinopathy , Pages 363-390 Chapter 22 - Protein Electrophoresis and Immunofixation , Pages 391-406 Chapter 23 - Human Immunodeficiency Virus (HIV) and Hepatitis Testing , Pages 407-425 Chapter 24 - Autoimmunity, Complement, and Immunodeficiency , Pages 427-447 Chapter 25 - Effect of Herbal Supplements on Clinical Laboratory Test Results , Pages 449-459 Index , Pages 461-483 Color Plates , Pages 485-488

All pathology residents must have a good command of clinical chemistry, toxicology, immunology, and laboratory statistics to be successful pathologists, as well as to pass the American Board of Pathology examination. Clinical chemistry, however, is a topic in which many senior medical students and pathology residents face challenges. Clinical Chemistry, Immunology and Laboratory Quality Control meets this challenge head on with a clear and easy-to-read presentation of core topics and detailed case studies that illustrate the application of clinical chemistry knowledge to everyday patient care.

This basic primer offers practical examples of how things function in the pathology clinic as well as useful lists, sample questions, and a bullet-point format ideal for quick pre-Board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this may be too much information for students, residents, and clinicians. This book is designed to educate senior medical students, residents, and fellows, and to "refresh" the knowledge base of practicing clinicians on how tests are performed in their laboratories (i.e., method principles, interferences, and limitations).

• Takes a practical and easy-to-read approach to understanding clinical chemistry and toxicology
• Covers all important clinical information found in larger textbooks in a more succinct and easy-to-understand manner
• Covers essential concepts in instrumentation and statistics in such a way that fellows and clinicians understand the methods without having to become specialists in the field
• Includes chapters on drug-herb interaction and pharmacogenomics, topics not covered by textbooks in the field of clinical chemistry or laboratory medicine

All pathology residents must have a good command of clinical chemistry, toxicology, immunology, and laboratory statistics to be successful pathologists, as well as to pass the American Board of Pathology examination. Clinical chemistry, however, is a topic in which many senior medical students and pathology residents face challenges. Clinical Chemistry, Immunology and Laboratory Quality Control meets this challenge head on with a clear and easy-to-read presentation of core topics and detailed case studies that illustrate the application of clinical chemistry knowledge to everyday patient care. This basic primer offers practical examples of how things function in the pathology clinic as well as useful lists, sample questions, and a bullet-point format ideal for quick pre-Board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this may be too much information for students, residents, and clinicians. This book is designed to educate senior medical students, residents, and fellows, and to'refresh'the knowledge base of practicing clinicians on how tests are performed in their laboratories (i.e., method principles, interferences, and limitations). Takes a practical and easy-to-read approach to understanding clinical chemistry and toxicology Covers all important clinical information found in larger textbooks in a more succinct and easy-to-understand manner Covers essential concepts in instrumentation and statistics in such a way that fellows and clinicians understand the methods without having to become specialists in the field Includes chapters on drug-herb interaction and pharmacogenomics, topics not covered by textbooks in the field of clinical chemistry or laboratory medicine