Cisplatin current status and new developments : [papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories, Syracuse, N.Y., held Sept. 27-28, 1979, in Atlanta, Ga

Content: Front Matter , Page i Copyright , Page ii CONTRIBUTORS , Pages vii-xiv PREFACE , Page xv Chapter 1 - CISPLATIN: A PRECLINICAL OVERVIEW , Pages 1-7 , Archie W. Prestayko Chapter 2 - CISPLATIN: ITS HISTORY AND POSSIBLE MECHANISMS OF ACTION , Pages 9-20 , Barnett Rosenberg Chapter 3 - EFFECTS OF CISPLATIN ON DNA AND THE POSSIBLE RELATIONSHIPS TO CYTOTOXICITY AND MUTAGENICITY IN MAMMALIAN CELLS , Pages 21-35 , Leonard A. Zwelling, Kurt W. Kohn Chapter 4 - THE LETHAL ACTIVITY OF PLATINUM COMPOUNDS IN COMBINATION WITH PYRIMIDINE DERIVATIVES , Pages 37-55 , Benjamin Drewinko, Peter Corry, John-Pierre Bergerat, Barthel Barlogie Chapter 5 - REPAIR OF cis -PLATINUM (II) DIAMMINE DICHLORIDE-INDUCED DNA DAMAGE AND CELL SENSITIVITY , Pages 57-77 , John J. Roberts, Hadrian N.A. Fraval Chapter 6 - ULTRASTRUCTURAL EFFECTS OF CISPLATIN , Pages 79-111 , Surinder K. Aggarwal, Michael W. Whitehouse, C. Ramachandran Chapter 7 - RATIONALE OF COMBINATION CHEMOTHERAPY , Pages 113-123 , Joseph H. Burchenal, Linda Lokys, John Turkevich, Glen Gale Chapter 8 - A REVIEW OF INTERACTIONS BETWEEN PLATINUM COORDINATION COMPLEXES AND IONIZING RADIATION: IMPLICATIONS FOR CANCER THERAPY , Pages 125-147 , Evan B. Douple, Robert C. Richmond Chapter 9 - ANTITUMOR PLATINUM COMPLEXES: STRUCTURE-ACTIVITY RELATIONSHIPS , Pages 149-170 , Michael J. Cleare, Paul C. Hydes, Deric R. Hepburn, Bernard W. Malerbi Chapter 10 - ANTITUMOR ACTIVITY OF PLATINUM ANALOGS , Pages 171-182 , William T. Bradner, William C. Rose, James B. Huftalen Chapter 11 - ANTITUMOR ACTIVITY OF CISPLATIN ANALOGS , Pages 183-191 , Mary K. Wolpert-DeFilippes Chapter 12 - ANTITUMOR, TOXIC AND BIOCHEMICAL PROPERTIES OF CISPLATIN AND EIGHT OTHER PLATINUM COMPLEXES , Pages 193-212 , Kenneth R. Harrap, Mervyn Jones, C. Ray Wilkinson, Hugh McD. Clink, Stephen Sparrow, Bernard C.V. Mitchley, Sylvia Clarke, Ann Veasey Chapter 13 - IN VITRO INTERACTION OF COVALENTLY LINKED CLOSED CIRCULAR DNA WITH THE SECOND-GENERATION PLATINUM COMPOUNDS , Pages 213-226 , Seymour Mong, Archie W. Prestayko, Stanley T. Crooke Chapter 14 - TOXIC SIDE EFFECTS OF PLATINUM ANALOGS , Pages 227-236 , John E. Schurig, William T. Bradner, James B. Huftalen, Gary J. Doyle, Jonas A. Gylys Chapter 15 - APPROACHES TO STUDIES OF PLATINATE TOXICITIES , Pages 237-248 , Anthony M. Guarino, David S. Miller, Susan T. Arnold, Mary A. Urbanek, Mary K. Wolpert-DeFilippes, Miles P. Hacker Chapter 16 - MORPHOLOGICAL MANIFESTATIONS OF CISPLATIN ANALOGS IN RATS: AN ULTRASTRUCTURAL STUDY , Pages 249-269 , Yerach Daskal, Archie W. Prestayko, Stanley T. Crooke Chapter 17 - RADIOPHARMACOKINETICS OF CISPLATIN , Pages 271-283 , Randall C. Manaka, Walter Wolf Chapter 18 - REACTIONS OF CISPLATIN WITH HUMAN PLASMA AND PLASMA FRACTIONS , Pages 285-304 , Arnold J. Repta, David F. Long Chapter 19 - PHYSICAL COMPATIBILITY AND CHEMICAL STABILITY OF CISPLATIN IN VARIOUS DILUENTS AND IN LARGE-VOLUME PARENTERAL SOLUTIONS , Pages 305-316 , Elio P. Mariani, Bruce J. Southard, John T. Woolever, Ronald H. Erlich, Alphonse P. Granatek Chapter 20 - CISPLATIN: A CLINICAL OVERVIEW , Pages 317-321 , John R. Durant Chapter 21 - CISPLATIN CHEMOTHERAPY OF TESTICULAR CANCER , Pages 323-328 , Stephen D. Williams, Lawrence H. Einhorn Chapter 22 - SEQUENTIAL COMBINATION CHEMOTHERAPY WITH VINBLASTINE-BLEOMYCIN AND ADRIAMYCIN-CISPLATIN IN EARLY AND LATE TESTICULAR CANCER , Pages 329-344 , Siegfried Seeber, Max E. Scheulen, Rudolf B. Schilcher, Markus Higi, Norbert Niederle, Despina Mouratidou, Werner C. Bierbaum, Carl G. Schmidt Chapter 23 - CISPLATIN ANALOGS AND COMBINATION CHEMOTHERAPY IN THE THERAPY OF MURINE BLADDER CANCER , Pages 345-359 , Mark S. Soloway, Steven B. Masters, William M. Murphy Chapter 24 - CISPLATIN REGIMENS IN THE TREATMENT OF BLADDER AND PENILE CANCER , Pages 361-374 , Alan Yagoda Chapter 25 - TREATMENT OF ADVANCED ADENOCARCINOMA OF THE PROSTATE WITH CISPLATIN , Pages 375-381 , Claude Merrin Chapter 26 - CISPLATIN THERAPY OF OVARIAN CANCER , Pages 383-391 , James F. Holland, Howard W. Bruckner, Carmel J. Cohen, Robert C. Wallach, Saul B. Gusberg, Ezra M. Greenspan, Judith Goldberg Chapter 27 - CISPLATIN COMBINATION CHEMOTHERAPY FOR DRUG-RESISTANT OVARIAN CARCINOMA , Pages 393-401 , David S. Alberts, Robert D. Hilgers, Thomas E. Moon, Robert O'Toole, Frank Mantz, Pierre W. Martimbeau, Ronald L. Stephens, Saul Rivkin, Nancy Mason Chapter 28 - CISPLATIN IN TREATMENT OF CERVICAL AND ENDOMETRIAL CANCER PATIENTS , Pages 403-409 , Laurence H. Baker Chapter 29 - CISPLATIN IN THE TREATMENT OF ADVANCED OR RECURRENT CERVIX AND UTERINE CANCER , Pages 411-421 , J. Tate Thigpen, Hugh Shingleton, Howard Homesley, Philip DiSaia, Leo Lagasse, John Blessing Chapter 30 - THE ROLE OF CISPLATIN IN THE TREATMENT OF RECURRENT HEAD AND NECK CANCER , Pages 423-430 , Charlotte Jacobs Chapter 31 - INDUCTION CHEMOTHERAPY OF ADVANCED PREVIOUSLY UNTREATED SQUAMOUS CELL HEAD AND NECK CANCER WITH CISPLATIN AND BLEOMYCIN , Pages 431-444 , Waun Ki Hong, Rakesh Bhutani, Stanley M. Shapshay, Stuart Strong Chapter 32 - CLINICAL RESULTS WITH CISPLATIN IN LUNG CANCER , Pages 445-458 , Daniel D. Von Hoff, David Elson Chapter 33 - THE USE OF INTRAVENOUS CISPLATIN IN VARIOUS ADULT MALIGNANCIES , Pages 459-464 , Michael A. Friedman Chapter 34 - CISPLATIN IN METASTATIC OSTEOGENIC SARCOMA , Pages 465-475 , Gerald Rosen, Anita Nirenberg, Brenda Caparros, Herbert Juergens, Charlotte Tan, Manuel Gutierrez Chapter 35 - PHASE II EVALUATION OF CISPLATIN IN CHILDREN WITH NEUROBLASTOMA AND OTHER MALIGNANT SOLID TUMORS , Pages 477-484 , Alexander A. Green, F. Ann Hayes, Charles B. Pratt, William E. Evans, Cathryn B. Howarth, Neil Senzer Chapter 36 - CISPLATIN NEPHROTOXICITY: THE EFFECT OF DOSE, SCHEDULE, AND HYDRATION SCHEME , Pages 485-494 , Robert L. Comis Chapter 37 - TREATMENT OF REGIONALLY CONFINED METASTATIC TUMORS WITH ARTERIAL INFUSION OF CISPLATIN , Pages 495-509 , Yehuda Z. Patt, Dionisio B. Calvo III, Robert S. Benjamin, Giora M. Mavligit Chapter 38 - DESIGN OF CLINICAL TRIALS WITH CISPLATIN ANALOGS , Pages 511-516 , Stephen K. Carter Chapter 39 - CLINICAL RESULTS WITH CISPLATIN ANALOGS , Pages 517-527 , Franco M. Muggia, Mary K. Wolpert-DeFilippes, Patricia Ribaud, Georges Mathé Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse,?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetics of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.