Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance (Experientia Supplementum Book 106)

MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance. Front Matter....Pages i-xii Front Matter....Pages 1-1 Introduction to microRNAs: Biogenesis, Action, Relevance of Tissue microRNAs in Disease Pathogenesis, Diagnosis and Therapy—The Concept of Circulating microRNAs....Pages 3-30 Extracellular microRNAs in Membrane Vesicles and Non-vesicular Carriers....Pages 31-53 Technical Aspects Related to the Analysis of Circulating microRNAs....Pages 55-71 Front Matter....Pages 73-73 Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors....Pages 75-122 Circulating microRNA as Biomarkers in Hematological Malignancies....Pages 123-138 Circulating microRNAs as Biomarkers in Cardiovascular Diseases....Pages 139-149 Circulating microRNAs in Neurodegenerative Diseases....Pages 151-169 Circulating Extracellular microRNA in Systemic Autoimmunity....Pages 171-195 Circulating microRNAs in Inflammatory Bowel Diseases....Pages 197-214 Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation....Pages 215-244 Diagnostic Relevance of microRNAs in Other Body Fluids Including Urine, Feces, and Saliva....Pages 245-252 Front Matter....Pages 253-253 Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?....Pages 255-267 Are Circulating microRNAs Involved in Tumor Surveillance?....Pages 269-280 Hypothetic Interindividual and Interspecies Relevance of microRNAs Released in Body Fluids....Pages 281-288