Ciba Foundation Symposium - Steroid Hormone Administration (Book II of Colloquia on Endocrinology), Volume III

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2 Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials , this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Relation Between Effect and Method of Administration of Androgens and Estrogens to Fowl (pages 248–253): A. S. Parkes Chapter 2 Some Data on Emulsions of Steroid Hormones (pages 254–262): C. A. Overbeek Chapter 3 Data on Relative Absorption Rates of Subcutaneous Pellets of Steroid —Hormones in Rats (pages 263–264): T. R. Forbes Chapter 4 Studies on the Absorption of Pellets of Steroid Hormones and Related Substances in Man (pages 265–282): P. M. F. Bishop and S. J. Folley Chapter 5 Absorption Data from Tablet Implantation Experiments in Ruminants (pages 283–290): F. H. Malpress Chapter 6 Data on Progesterone Physiology and Metabolism (pages 291–303): T. R. Forbesw Chapter 7 17?Ketosteroid Excretion and Modes of Administering Testosterone Preparations (pages 304–322): Christian Hamburger Chapter 8 Administration of Sex Hormones and Sexual Behaviour (pages 323–337): M. Klein Chapter 9 Artificial Induction of Lactation in Goats by Steroid Hormones and Synthetic Estrogens (pages 338–348): A. T. Cowie Chapter 10 The Difficulty of Evaluating the Potency of Steroid Hormones by Different Routes of Administration in Humans (pages 349–355): P. M. F. Bishop Chapter 11 Observations on the Results of Pharmacological Assay of Synthetic Estrogens and Their Clinical Effects (pages 356–360): W. A. Broom Chapter 12 Clinical Impressions of Values of ?strogens and Androgens Administered by Different Routes (pages 361–369): G. L. Foss Chapter 13 Chairman's Closing Remarks (pages 370–374): J. H. Gaddum Volume 1 __Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs__ successfully upholds the goals of the __Wiley Encyclopedia of Clinical Trials__ by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2 Featuring newly-written material as well as established literature from the __Wiley Encyclopedia of Clinical Trials__, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Relation Between Effect and Method of Administration of Androgens and Estrogens to Fowl (pages 248–253): A. S. ParkesChapter 2 Some Data on Emulsions of Steroid Hormones (pages 254–262): C. A. OverbeekChapter 3 Data on Relative Absorption Rates of Subcutaneous Pellets of Steroid —Hormones in Rats (pages 263–264): T. R. ForbesChapter 4 Studies on the Absorption of Pellets of Steroid Hormones and Related Substances in Man (pages 265–282): P. M. F. Bishop and S. J. FolleyChapter 5 Absorption Data from Tablet Implantation Experiments in Ruminants (pages 283–290): F. H. MalpressChapter 6 Data on Progesterone Physiology and Metabolism (pages 291–303): T. R. ForbeswChapter 7 17?Ketosteroid Excretion and Modes of Administering Testosterone Preparations (pages 304–322): Christian HamburgerChapter 8 Administration of Sex Hormones and Sexual Behaviour (pages 323–337): M. KleinChapter 9 Artificial Induction of Lactation in Goats by Steroid Hormones and Synthetic Estrogens (pages 338–348): A. T. CowieChapter 10 The Difficulty of Evaluating the Potency of Steroid Hormones by Different Routes of Administration in Humans (pages 349–355): P. M. F. BishopChapter 11 Observations on the Results of Pharmacological Assay of Synthetic Estrogens and Their Clinical Effects (pages 356–360): W. A. BroomChapter 12 Clinical Impressions of Values of ?strogens and Androgens Administered by Different Routes (pages 361–369): G. L. FossChapter 13 Chairman's Closing Remarks (pages 370–374): J. H. Gaddum The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.