Ciba Foundation Symposium on the nature of viruses [held in London, 26th-28th March, 1956

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2 Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials , this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Virus Structure: General Principles (pages 5–18): F. H. C. Crick and J. D. Watson Chapter 2 Structure and Substructure of Viruses as Seen Under the Electron Microscope (pages 19–38): Robley C. Williams Chapter 3 X?Ray Diffraction Studies of the Structure and Morphology of Tobacco Mosaic Virus (pages 39–55): Rosalind E. Franklin, A. Klug and K. C. Holmes Chapter 4 Material in Virus Preparations not Necessary for the Manifestation of Characteristic Virus Properties (pages 56–68): N. W. Pirie Chapter 5 Some Recent Developments in the Chemistry of Virus Mutants (pages 69–90): C. A. Knight Chapter 6 Units Isolated After Splitting Fowl Plague Virus (pages 91–103): Werner Schafer Chapter 7 Ribonucleic Acid in Influenza Virus (pages 104–122): G. L. Ada Chapter 8 Chemical Inactivation of Viruses (pages 123–146): Sven Gard Chapter 9 Quantitative Aspects of Virus Growth in Cultivated Animal Cells (pages 147–157): R. Dulbecco Chapter 10 The Multiplication of Animal Viruses (pages 158–169): F. K. Sanders Chapter 11 The Multiplication of Plant Viruses (pages 170–190): F. C. Bawden Chapter 12 Studies on Mixed Infections with Influenza Viruses (pages 191–202): George K. Hirst, Tamar Gotlieb and Allan Granoff Chapter 13 The Morphological Aspects of Virus Infections of Cells as Revealed by Fluorescent Antibody (pages 203–210): Albert H. Coons Chapter 14 The Use of Radioactive Influenza Virus to Determine the Fate of the Infecting Particle on Entry into the Host Cell (pages 211–223): L. Hoyle Chapter 15 The Size Distribution of Specific Antigens in Virus?Infected Tissues and their Significance (pages 224–248): A. Kipps, W. du T. Naude, A. Polson, G. Selzer and M. Van Den Ende Chapter 16 Morphological Aspects of Virus Cell Relationships in Influenza, Mumps and Newcastle (Myzovirus) (pages 249–262): F. B. Bang and A. Isaacs Chapter 17 Interaction of Phages with Bacterial Cell Walls and the Development of Phage in the Wall?Less Protoplast (pages 263–276): M. R. J. Salton Chapter 17a General Discussion (pages 276–286): Volume 1 __Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs__ successfully upholds the goals of the __Wiley Encyclopedia of Clinical Trials__ by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2 Featuring newly-written material as well as established literature from the __Wiley Encyclopedia of Clinical Trials__, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Virus Structure: General Principles (pages 5–18): F. H. C. Crick and J. D. WatsonChapter 2 Structure and Substructure of Viruses as Seen Under the Electron Microscope (pages 19–38): Robley C. WilliamsChapter 3 X?Ray Diffraction Studies of the Structure and Morphology of Tobacco Mosaic Virus (pages 39–55): Rosalind E. Franklin, A. Klug and K. C. HolmesChapter 4 Material in Virus Preparations not Necessary for the Manifestation of Characteristic Virus Properties (pages 56–68): N. W. PirieChapter 5 Some Recent Developments in the Chemistry of Virus Mutants (pages 69–90): C. A. KnightChapter 6 Units Isolated After Splitting Fowl Plague Virus (pages 91–103): Werner SchaferChapter 7 Ribonucleic Acid in Influenza Virus (pages 104–122): G. L. AdaChapter 8 Chemical Inactivation of Viruses (pages 123–146): Sven GardChapter 9 Quantitative Aspects of Virus Growth in Cultivated Animal Cells (pages 147–157): R. DulbeccoChapter 10 The Multiplication of Animal Viruses (pages 158–169): F. K. SandersChapter 11 The Multiplication of Plant Viruses (pages 170–190): F. C. BawdenChapter 12 Studies on Mixed Infections with Influenza Viruses (pages 191–202): George K. Hirst, Tamar Gotlieb and Allan GranoffChapter 13 The Morphological Aspects of Virus Infections of Cells as Revealed by Fluorescent Antibody (pages 203–210): Albert H. CoonsChapter 14 The Use of Radioactive Influenza Virus to Determine the Fate of the Infecting Particle on Entry into the Host Cell (pages 211–223): L. HoyleChapter 15 The Size Distribution of Specific Antigens in Virus?Infected Tissues and their Significance (pages 224–248): A. Kipps, W. du T. Naude, A. Polson, G. Selzer and M. Van Den EndeChapter 16 Morphological Aspects of Virus Cell Relationships in Influenza, Mumps and Newcastle (Myzovirus) (pages 249–262): F. B. Bang and A. IsaacsChapter 17 Interaction of Phages with Bacterial Cell Walls and the Development of Phage in the Wall?Less Protoplast (pages 263–276): M. R. J. SaltonChapter 17a General Discussion (pages 276–286): The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.