Ciba Foundation Symposium 94 - Malaria and the Red Cell: Ciba/Malaria

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2 Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials , this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Introduction (pages 1–2): D.J. Weatherall Chapter 2 Erythrocyte Membrane Structure and Function (pages 3–23): M. J. A. Tanner Chapter 3 Maturation of the Intracellular Parasite and Antigenicity (pages 24–44): K. N. Brown, D. B. Boyle and C. I. Newbold Chapter 4 Structural Alteration of the Erythrocyte Membrane During Malarial Parasite Invasion and Intraerythrocytic Development (pages 45–63): Masamichi Aikawa and Louis H. Miller Chapter 5 Transport of Ions in Erythrocytes Infected by Plasmodia (pages 64–73): Kazuyuki Tanabe, Ross B. Mikkelsen and Donald F. H. Wallach Chapter 6 The Anaemia of Plasmodium falciparum Malaria (pages 74–97): D. J. Weatherall, S. Abdalla and M. J. Pippard Chapter 7 The Spleen in Malaria (pages 98–116): David J. Wyler Chapter 8 Influence of the Spleen on the Expression of Surface Antigens on Parasitized Erythrocytes (pages 117–136): John W. Barnwell, Russell J. Howard and Louis H. Miller Chapter 9 Protective Immunity to Malaria and Anti?Erythrocyte Autoimmunity (pages 137–158): W. Jarra Chapter 10 Genetic Variation in the Host and Adaptive Phenomena in Plasmodium falciparum Infection (pages 159–173): L. Luzzatto, F, O. Sodeinde and G. Martinit Chapter 11 Glycophorins and Red Cell Invasion by Plasmodium falciparum (pages 174–195): Geoffrey Pasvol and Michele Jungery Chapter 12 Expression of Inherited Resistance to Malaria in Culture (pages 196–205): Milton J. Friedman Chapter 13 Metabolism and Surface Transport of Parasitized Erythrocytes in Malaria (pages 206–221): Irwin W. Sherman Chapter 14 Mode of Action of Antimalarial Drugs (pages 221–245): Coy D. Fitch Chapter 15 Closing Remarks (pages 246–247): D.J. Weatherall Volume 1 __Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs__ successfully upholds the goals of the __Wiley Encyclopedia of Clinical Trials__ by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2 Featuring newly-written material as well as established literature from the __Wiley Encyclopedia of Clinical Trials__, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Introduction (pages 1–2): D.J. WeatherallChapter 2 Erythrocyte Membrane Structure and Function (pages 3–23): M. J. A. TannerChapter 3 Maturation of the Intracellular Parasite and Antigenicity (pages 24–44): K. N. Brown, D. B. Boyle and C. I. NewboldChapter 4 Structural Alteration of the Erythrocyte Membrane During Malarial Parasite Invasion and Intraerythrocytic Development (pages 45–63): Masamichi Aikawa and Louis H. MillerChapter 5 Transport of Ions in Erythrocytes Infected by Plasmodia (pages 64–73): Kazuyuki Tanabe, Ross B. Mikkelsen and Donald F. H. WallachChapter 6 The Anaemia of Plasmodium falciparum Malaria (pages 74–97): D. J. Weatherall, S. Abdalla and M. J. PippardChapter 7 The Spleen in Malaria (pages 98–116): David J. WylerChapter 8 Influence of the Spleen on the Expression of Surface Antigens on Parasitized Erythrocytes (pages 117–136): John W. Barnwell, Russell J. Howard and Louis H. MillerChapter 9 Protective Immunity to Malaria and Anti?Erythrocyte Autoimmunity (pages 137–158): W. JarraChapter 10 Genetic Variation in the Host and Adaptive Phenomena in Plasmodium falciparum Infection (pages 159–173): L. Luzzatto, F, O. Sodeinde and G. MartinitChapter 11 Glycophorins and Red Cell Invasion by Plasmodium falciparum (pages 174–195): Geoffrey Pasvol and Michele JungeryChapter 12 Expression of Inherited Resistance to Malaria in Culture (pages 196–205): Milton J. FriedmanChapter 13 Metabolism and Surface Transport of Parasitized Erythrocytes in Malaria (pages 206–221): Irwin W. ShermanChapter 14 Mode of Action of Antimalarial Drugs (pages 221–245): Coy D. FitchChapter 15 Closing Remarks (pages 246–247): D.J. Weatherall The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.