Ciba Foundation Symposium 75 - Protein Degradation in Health and Disease: Ciba/Protein

Content: Chapter 1 Introduction: The Classification of Proteinases (pages 1–13): Alan J. Barrett Chapter 2 Lysosomal Cysteine Proteinases (pages 15–35): H. Kirschke, J. Langner, S. Riemann, B. Wiederanders, S. Ansorge and P. Bohley Chapter 3 Cathepsin D: The Lysosomal Aspartic Proteinase (pages 37–50): Alan J. Barrett Chapter 4 Human Leucocyte Elastase and Cathepsin G: Structural and Functional Characteristics (pages 51–68): James Travis, P.J. Giles, L. Porcelli, C.F. Reilly, R. Baugh and J. Powers Chapter 5 Human Collagenases: Comparative and Immunolocalization Studies (pages 69–86): David E. Woolley Chapter 6 Proteinases in Connective Tissue Breakdown (pages 87–103): David J. Etherington Chapter 7 Cellular Mechanisms of Proteinase Release from Inflammatory Cells and the Degradation of Extracellular Proteins (pages 105–121): Marco Baggiolini, Jorg Schnyder, Ursula Bretz, Beatrice Dewald and Walter Ruch Chapter 8 Inactivation of Cytosol Enzymes by a Liver Membrane Protein (pages 123–137): G.L. Francis, S.E. Knowles and F.J. Ballard Chapter 9 Lysosomes and Protein Degradation (pages 139–149): Roger T. Dean Chapter 10 Insights into Mechanisms of Intracellular Protein Turnover from Studies on Pinocytosis (pages 151–165): J.B. Lloyd Chapter 11 Turnover and Degradation of Mitochondria and Their Proteins (pages 167–188): Santiago Grisolia, Erwin Knecht, Jose Hernandez?Yago and Ruth Wallace Chapter 12 Protein Degradation in Cells in Culture (pages 189–203): Brian Poole, Shoji Ohkuma and Michael Warburton Chapter 13 Regulation of Protein Breakdown in Hepatocyte Monolayers (pages 205–218): M.F. Hopgood and F.J. Ballard Chapter 14 A Possible Role for Neutral Proteolysis in the Degradation of Intracellular Proteins (pages 219–225): John Kay Chapter 15 Studies of the ATP Dependence of Protein Degradation in Cells and Cell Extracts (pages 227–251): Alfred L. Goldberg, Nina P. Strnad and K.H. Sreedhara Swamy Chapter 16 Coordination of Protein Synthesis and Degradation (pages 253–280): R. John Mayer, Susan M. Russell, Rowland J. Burgess, Colin J. Wilde and Norman Paskin Chapter 17 Application of Liver Perfusion as an in vitro Model in Studies of Intracellular Protein Degradation (pages 281–305): Glenn E. Mortimore and Charles M. Schworer Chapter 18 Protein Degradation and the Regulation of Protein Balance in Muscle (pages 307–329): D.J. Millward, P.C. Bates, J.G. Brown, S.R. Rosochacki and M.J. Rennie Chapter 19 Protein Degradation in Metabolic and Nutritional Disorders (pages 331–350): J. Fred Dice and Carlos D. Walker Chapter 20 Proteinase Inhibitors in Severe Inflammatory Processes (Septic Shock and Experimental Endotoxaemia): Biochemical, Pathophysiological and Therapeutic Aspects (pages 351–379): Hans Fritz Chapter 21 Neutral Proteinases of Leucocytes and the Inflammatory Process (pages 381–402): J.?D. Vassalli, A. Granelli?Piperno and E. Reich Chapter 22 Concluding Remarks (pages 403–406): Alan J. Barrett The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.