Ciba Foundation Symposium 48 - Purine and Pyrimidine Metabolism: Ciba/Purine

Content: Chapter 1 Chairman's Opening Remarks (pages 1–2): R. W. E. Watts Chapter 2 Purine and Pyrimidine Metabolism: Pathways, Pitfalls and Perturbations (pages 3–21): J. Frank Henderson, Jeffrey K. Lowe and Jerzy Barankiewicz Chapter 3 Microbial Models and Regulatory Elements in the Control of Purine Metabolism (pages 23–41): Josepha S. Gots, Charles E. Benson, Bjarne Jochimsen and K. R. Koduri Chapter 4 Molecular Nature of Enzyme Regulation in Purine Biosynthesis (pages 43–64): James B. Wyngaarden and Edward W. Holmes Chapter 5 Genetic Heterogeneity at the Locus for Hypoxanthine?Guanine Phosphoribosyltransferase (pages 65–81): William L. Nyhan Chapter 6 Factors in the Pathogenesis of the Brain Damage and Anaemia in the Lesch?Nyhan Syndrome (pages 83–96): R.O. Mckeran Chapter 7 Hypoxanthine?Guanine Phosphoribosyltransferase Activity in Individual Erythrocytes: Autoradiographic Studies in Heter Ozygotes (pages 97–104): B. T. Emmerson, R. B. Gordon and L. A. Johnson Chapter 8 Purine Biosynthesis in Mutant Mammalian Cells (pages 105–126): Gabrielle H. Reem Chapter 9 Purine and Pyrimidine Nucleotides in Some Mutant Human Lymphoblasts (pages 127–142): G. Nuki, K. Astrini, D. Brenton, M. Cruikshank, J. Lever and J. E. Seegmiller Chapter 10 Superactivity of Phosphoribosylpyrophosphate Synthetase, due to Feedback Resistance, Causing Purine Overproduction and Gout (pages 143–164): Oded Sperling, Pnina Boer, Sara Brosh, Esther Zoref and Andre de Vries Chapter 11 Dietary Feedback Regulation of Purine and Pyrimidine Biosynthesis in Man (pages 165–178): N. Zollner and W. Grobner Chapter 12 Implications of Disorders of Purine Metabolism for the Kidney and the Urinary Tract (pages 179–206): Andre de Vries and Oded Sperling Chapter 13 The Role of de novo Purine Synthesis in Lymphocyte Transformation (pages 207–224): A. C. Allison, T. Hovi, R. W. E. Watts and A. D. B. Webster Chapter 14 Purine Metabolism and Control of Cell Proliferation (pages 225–248): Tapani Hovi, Tapani Hovi, Anthony C. Allison, Kari O. Raivio and Antti Vaheri Chapter 15 The Effect of Adenosine on Lymphoid Cell Proliferation and Antibody Formation (pages 249–276): J. Edwin Seegmiller, T. Watanabe and Max H. Schreier Chapter 16 Characterization of Human Adenosine Deaminase (pages 277–293): William N. Kelley, Peter E. Daddona and Martin B. van der Weyden Chapter 17 The Purinergic Nerve Hypothesis (pages 295–314): Geoffrey Burnstock Chapter 18 Inherited Metabolic Disease: Prospects for the Future in Both Basic and Clinical Research (pages 315–355): R. W. E. Watts The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.