Ciba Foundation Symposium 183 ‐ Circadian Clocks and their Adjustment: Circadian Clocks and their Adjustment: Ciba Foundation Symposium 183

Prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. Also considers the implications of the basic and clinical research for humans. Content: Genetic Basis Of The Circadian Clock : Identification Of Frq And Frq As Clock Components In Neurospora / J.c. Dunlap [and Others] -- Effects Of Temperature Change On The Circadian Clock Of Neurospora / L. Rensing [and Others] -- Cellular Analysis Of A Molluscan Retinal Biological Clock / G. Block [and Others] -- Circadian Pacemakers In Vertebrates / M.r. Ralph, M.w. Hurd -- Organization Of The Mammalian Circadian System / R.y. Moore -- Effects Of Light On The Gonyaulax Circadian System / T. Roenneberg -- Intrinsic Neuronal Rhythms In The Suprachiasmatic Nuclei And Their Adjustment / M.u. Gillette [and Others] -- Non-photic Gateway To The Circadian Clock Of Hamsters / N. Mrosovsky -- Immediate-early Genes And The Neuronal Bases Of Photic And Non-photic Entrainment / M.h. Hastings [and Others] -- Interaction Between The Circadian Clocks Of Mother And Fetus / S.m. Reppert -- Alterations In The Circadian System In Advanced Age / F.w. Turek [and Others] -- Clinical Chronopharmacology : The Importance Of Time In Drug Treatment / B. Lemmer -- Effect Of Light On The Human Circadian Pacemaker / C.a. Czeisler -- Melatonin Marks Circadian Phase Position And Resets The Endogenous Circadian Pacemaker In Humans / A.j. Lewy [and Others]. [editors, Derek J. Chadwick (organizer), And Kate Ackrill]. Symposium On Circadian Clocks And Their Adjustment, Held At The Ciba Foundation, London, 7-9 September 1993. Includes Bibliographical References And Index. This book covers recent advances in all major aspects of research on circadian clocks. The genetic and molecular basis of the clock in Neurospora crassa is described and the molecular background to recent work showing that individual isolated neurons from Bulla gouldiana can act as pacemakers is investigated. The organization and operation of circadian pacemakers in vertebrates is dealt with in the hamster and the rat; (...) Aspects of the book with direct relevance to humans include chapters on the importance of circadian time in clinical pharmacology and on the adjustment of the pacemaker by light and melatonin treatment in disorders such as shift-work dyssomnia and jet lag. [Editeur] This study describes the molecular, genetic, anatomical and neurochemical mechanisms and pathways that operate to control and regulate circadian clock signals in organisms. It also considers the implications of this research for humans