Ciba Foundation Symposium 176 ‐ The GTPase Superfamily: The GTPase superfamily: Ciba Foundation Symposium 176

Using a multidisciplinary approach, it features contributions and discussions of the latest research from leading scientists working on all aspects of GTPase activity. Covers all known members of the important superfamily of enzymes--the GTPases. Considers numerous key cellular functions and how they are regulated by GTPases. Also describes various regulatory proteins that modulate GTPase activity. Content: Three-dimensional Structure And Properties Of Wild-type And Mutant H-ras-encoded P21 / A. Wittinghofer [and Others] -- Elongation Factors In Protein Synthesis / B. Kraal [and Others] -- Ras Function And Protein Kinase Cascades / S. Marcus [and Others] -- Cell Transformation By Ras And Regulation Of Its Protein Product / D.r. Lowy [and Others] -- Identification Of Ras Targets Using A Genetic Approach / U. Gaul [and Others] -- G Proteins In Signal Transduction: The Regulation Of Phospholipase C / P.c. Sternweis And A.v. Smrcka -- G Protein Cascade Of Visual Transduction: Kinetics And Regulation / M. Chabre [and Others] -- Voltage-dependent Ca2 Channels As Gaps -- Regulators Of Small Gtpases / Y. Takai [and Others] -- Gtpase Cycle In Iniation Of Protein Translocation Across The Endoplasmic Reticulum Membrane / J.d. Miller And P. Walter -- Cell-physiological Description Of Ge, A Gtp-binding Protein That Mediates Exocytosis / T.h.w. Lillie And B.d. Gomperts -- Dynamin, A Gtpase Involved In The Initial Stages Of Endocytosis / R.b. Vallee [and Others] -- Vpsi Protein Is A Dynamin-like Gtpase Required For Sorting Proteins To The Yeast Vacuole / K. Ekena [and Others] -- Ras-mediated Signalling Pathway During Vulval Development In Caenorhabditis Elegans -- Cycle Of Sec4 Function In Vesicular Transport / P. Novick [and Others] -- Mx Proteins: Gtpases Involved In The Interferon-induced Antiviral State / J. Pavlovic [and Others] -- Should The Tubulins Be Members Of The Gtpase Superfamily? / R.g. Burns, K.w. Farrell And C.d. Surridge. [editors, Joan Marsh, Jamie Goode]. Based On A Symposium Held At The Ciba Foundation, London, 17-19 November 1992. A Wiley-interscience Publication. Includes Bibliographical References And Indexes. This volume contains the proceedings of an international symposium which discussed the many members of the GTPase superfamily, with emphasis on their common property of developing increased affinity for a target when bound to GTP, and losing that affinity when GTP is hydrolysed.