Ciba Foundation Symposium 167 ‐ Polyfunctional Cytokines: IL‐6 and LIF: Polyfunctional Cytokines: IL‐6 and LIF: Ciba Foundation Symposium 167

Experts from a variety of areas compare and discuss IL-6 and LIF in order to provide a new understanding of their modes of action, the significance of their polyfunctionalization--why the body chooses to use one molecule to regulate various cell types--and their functional overlap. Covers such topics as actions of IL-6 and LIF on lymphoid populations, on megakaryocyte and platelet production, on bone metabolism, their effects on leukemic cells and much more. Includes contributions from researchers working on a variety of cell types and organ systems along with potential clinical applications regarding these two factors. Content: Introduction / D. Metcalf -- Molecular Biology Of Interleukin 6 And Its Receptor / T. Kishimoto, M. Hibi, M. Murakami, M. Narazaki, M. Saito And T. Taga -- Molecular Biology Of The Leukaemia Inhibitory Factor Gene / N. M. Gough, T. A. Willson, J. Stahl And M. A. Brown -- Regulation Of Expression Of The Interleukin 6 Gene: Structure And Function Of The Transcription Factor Nf-il6 / S. Akira, H. Isshiki, T. Nakajima, S. Kinoshita, Y. Nishio, S. Natsuka And T. Kishimoto -- Action Of Interleukin 6 On Lymphoid Populations / L. A. Aarden And C. Van Kooten -- Regulation Of Leukaemic Cells By Interleukin 6 And Leukaemia Inhibitory Factor / J. Lotem And L. Sachs -- Action Of Interleukin 6 And Leukaemia Inhibitory Factor On Liver Cells / H. Baumann, S. Marinkovic-pajovic, K.-a. Won, V. E. Jones, S. P. Campos, G. P. Jahreis And K. K. Morella -- Further Studies Of The Distribution Of Cdf/lif Mrna / P. H. Patterson And M.-j. Fann -- Leukaemia Inhibitory Factor And Bone Cell Function / T. J. Martin, E. H. Allan, R. S. Evely And I. R. Reid -- General Discussion I : Acute-phase Responses -- Role Of Interleukin 6 In Megakaryocyte Formation, Megakaryocyte Development And Platelet Production / N. Williams, I. Bertoncello, H. Jackson, J. Arnold And H. Kavnoudias -- Actions Of Leukaemia Inhibitory Factor On Megakaryocyte And Platelet Formation / D. Metcalf, P. Waring And N. A. Nicola -- Role Of Interleukin 6 In Plasmacytomagenesis / T. Hirano, S. Suematsu, T. Matsusaka, T. Matsuda And T. Kishimoto -- General Discussion Ii : Interleukin 6, Leukaemia Inhibitory Factor And Granulocyte Colony-stimulating Factor ; Effects Of Leukaemia Inhibitory Factor And Interleukin 6 On Vascular Function -- Interleukin 6 Determination In The Detection Of Microbial Invasion Of The Amniotic Cavity / R. Romero, W. Sepulveda, J. S. Kenney, L. E. Archer, A. C. Allison And P. B. Sehgal -- General Discussion Iii : Multimeric Nature Of Human Interleukin 6 -- Distribution And Binding Properties Of Receptors For Leukaemia Inhibitory Factor / D. J. Hilton, N. A. Nicola And D. Metcalf -- Reconstitution Of High Affinity Leukaemia Inhibitory Factor (lif) Receptors In Haemopoietic Cells Transfected With The Cloned Human Lif Receptor / D. P. Gearing, T. Vandenbos, M. P. Beckmann, C. J. Thut, M. R. Comeau, B. Mosley And S. F. Ziegler -- General Discussion Iv : Cytokines And Binding Proteins In The Circulation ; Role Of Leukaemia Inhibitory Factor And Interleukin 6 In Tumorigenesis -- Summing-up / D. Metcalf. Editors, Gregory R. Bock (organizer) And Kate Widdows. A Wiley-interscience Publication. Includes Bibliographical References And Index. A selection of symposium papers which discuss and compare IL-6 and LIF and attempt to provide an understanding of their modes of action. The contributors assess why the body chooses to use one molecule to regulate a variety of cell types.