Ciba Foundation Symposium 141 ‐ Metastasis: Metastasis: Ciba Foundation Symposium 141

An international group of researchers addresses basic mechanism involved in the metastatic spread of tumors and considers new methods of prevention and treatment. Compares behavior of normal and abnormal cells, with emphasis on cell surface mechanisms--especially invasive processes--and inhibitors that might prevent metastasis. Also discusses determination of the metastatic genotype, the role of the immune system, and reduction of metastasis via liposome-activated macrophages. Content: Tissue Organizational Stability And Intercellular Invasion / Peter B. Armstrong -- Functional Role Of Specific Secreted And Cell Surface Molecules Inc Tumour Cell Invasion And Metastasis / James P. Quigley, Lee M. Sullivan, Catherine M. Demarinis, Joseph R. Gordon -- Adhesion Mechanisms In Embryogenesis And In Cancer Invasion And Metastasis / Jean Paul Thiery, Brigitte Boyer, Gordon Tucker, Jelena Gavrilovic, Ana-maria Valles -- The Cell Interaction Sites Of Fibronectin In Tumour Metastasis / Martin J. Humphries, Yoshiaki Yasuda, Kenneth Olden, Kenneth M. Yamada -- Oncogene Induction Of Metastases / Lance A. Liotta -- Adhesive Properties Of Metastasizing Tumour Cells / Avraham Raz -- Clonal Changes In Tumours During Growth And Progression Evaluated By Southern Gel Analysis Of Random Integrations Of Foreign Dna / R.s. Kerbel, Carol Waghorne, Bozena Korczak, Martin L. Breitman -- Molecular Genetics Of Metastasis / D. Tarin -- The Reversal Of The Metastatic Phenotype By Gene Transfer / M. Feldman, C. Gelber, D. Plaksin, G. Kushtai, L. Eisenbach -- Inhibitors Of Collagenase Iv And Cell Adhesion Reduce The Invasive Activity Of Malignant Tumour Cells / Reuven Reich, Bridget Stratford, Karen Klein, George R. Martin, Richard A. Mueller, George C. Fuller -- Macrophage Therapy Of Cancer Metastasis / Isaiah J. Fidler -- Clinical Aspects Of Metastases / Michael Peckham. Symposium On Metastasis, Held At The Ciba Foundation, London, 19-21 April 1988. Editors: Gregory Bock (organizer) And Julie Whelan --p. A Wiley-interscience Publication. Includes Bibliographies And Indexes. This volume contains the proceedings of a Ciba Foundation symposium on metastasis, held 19th-21st April 1988 in London. The papers presented at this conference ranged in topic from tissue organizational stability and intercellular invasion to molecular genetics and clinical aspects of metastasis. Intercellular invasion is defined as the intrusion of one tissue into space occupied by second tissue (Abercrombie 1970).