Chronomics and Continuous Ambulatory Blood Pressure Monitoring : Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring

This fascinating volume applies the concept of chronomics to the medical treatment of hypertension. It starts with the recent updates on chronomics, the analytic techniques, and their application to community-based assessments. The authors advocate the use of 7-day/24-h records of blood pressure, which is effective for finding masked hypertension, masked morning surge, and other rhythm abnormalities. Most organisms, from cyanobacteria to mammals, are known to use the circadian mechanism. However, our body systems also demonstrate circaseptan (roughly weekly), circannual (roughly yearly), and even longer rhythms. Chronomics monitors the physiological data and then analyzes the superimposed rhythms, isolating the cycles mathematically to determine how organisms and their environment interact. It is the study of interactions among time structures (chronomes) in and around us. Front Matter....Pages i-lxxv From Chronobiology to Chronomedicine: Early Days....Pages 1-51 From Chronomics to Chronoastrobiology: Many Rhythms Are Control Information for Whatever We Do....Pages 53-98 Chronobioethics: What Is Life?....Pages 99-162 Chronobiology....Pages 163-184 Chronomics of Heart Rate Variability....Pages 185-214 Chronomics of Life for Improving the Quality of Health....Pages 215-259 Chronomics of Tree Rings Gauge Climate Change....Pages 261-269 Introduction to Chronobioengineering....Pages 271-303 What Community-Based Glocal Comprehensive Assessment Tells Us: Chronoecology Is Far Superior to Evidence-Based Medicine (EBM)....Pages 305-312 Community-Based Comprehensive Geriatric Assessment....Pages 313-318 Chronomic Community Screening: Depressive Mood, Heart Rate Variability, and Cardiovascular Outcomes in a Community....Pages 319-345 Chronoecological “Glocal” (Global and Local) Comprehensive Health-Watch at High Altitude....Pages 347-357 Chronoastrobiology....Pages 359-403 Heart Rate Variability Reflecting the Dynamics of Solar Activity....Pages 405-428 A Transdisciplinary Near-Transyear in Sudden Cardiac Death Validates Its Counterpart in the Solar Wind and Geomagnetics....Pages 429-458 Diagnosing Vascular Variability Disorders and Vascular Variability Syndromes....Pages 459-479 Among-Day Blood Pressure Variability Assessed by 7-Day/24-Hour Ambulatory Blood Pressure Monitoring and Prognostic Value of Vascular Variability Anomalies....Pages 481-497 Case Presentations I. Within-Day BP Variations Observed Using 7-Day/24-Hour Ambulatory BP Monitoring....Pages 499-543 Case Presentations II. Vascular Variability Syndrome....Pages 545-601 Case Presentations III: Among-Day Variability of Circadian Profiles of 24-Hour ABP....Pages 603-659 “What Is Life?” Cycles Tipping the Scale Between Death and Survival....Pages 661-736 Astro-glocal Spatially and Temporally (Global and Local) Comprehensive Health-Watch Especially at High Altitude....Pages 737-754 Chronobioethics and Alerting Chronobiologic Ambulatory Blood Pressure Monitoring (C-ABPM; Stress/Strain Test) for Preventing Cardiovascular and for Understanding and Avoiding/Evading Societal and Natural Cataclysms by Personalized and Generalized Chronouspheres....Pages 755-864 Back Matter....Pages 865-870 1.3 Epinephrine Test of Adrenocortical Function? -- 1.4 Vascular Variability Disorders (VVDs) -- 1.5 "Norms", No Substitute for Concomitant Controls: The Adrenal Cycle, Loads, Baselines, and Spot Checks -- 1.6 Telemetry -- 1.7 "Circadian" and "Free-Running" over 60 Years Later -- References -- Chapter 2: From Chronomics to Chronoastrobiology: Many Rhythms Are Control Information for Whatever We Do -- 2.1 Back to My First Encounter with the Adrenocortical Cycle -- 2.2 Life or Death from the Same Stimulus, Including Drugs: Chronotherapy -- 2.3 Cellular Timing -- 2.4 Prokaryotes -- 2.5 Eukaryotes 4.3.6 Circaseptans and Circasemiseptans -- 4.3.7 Circatrigintans -- 4.3.8 Circannuals -- 4.4 Conclusion -- References -- Chapter 5: Chronomics of Heart Rate Variability -- 5.1 Introduction -- 5.2 Mapping of Chronome Components -- 5.3 Circadian Elements in Chronomics -- 5.4 Circadian Reference Values for Different Endpoints of HRV -- 5.5 Developmental Trends in Frequency-Domain HRV Indices -- 5.6 Age Trends in Heart Rate Variability -- 5.7 Gender Difference in HRV -- 5.8 Age Trends in HRV Chronodesm -- 5.9 Nonlinear Elements of HRV Chronomics -- 5.10 A Broadening Spectral Element of Chronomics Dedication -- Preface -- Chronobiology -- Blood Pressure -- A Note to the Reader -- References -- A Brief Overview of Professor Franz Halberg's Life and Work -- Acknowledgments -- Chronomedicine -- 1981 -- 1982 -- 1983 -- 1984 -- 1985 -- 1986 -- 1987 -- 1988 -- 1989 -- 1990 -- 1991 -- 1992 -- 1993 -- 1994 -- 1995 -- 1996 -- 1997 -- 1998 -- 1999 -- 2000 -- 2001 -- 2002 -- 2003 -- 2004 -- 2005 -- 2006 -- 2007 -- 2008 -- 2009 -- 2010 -- 2011 -- 2012 -- 2013 -- 2014 -- Chronoecology -- 2002 -- 2003 -- 2004 -- 2005 -- 2006 -- 2007 -- 2008 -- 2009 -- 2010 -- 2011 -- 2012 -- 2014 2.6 Infradians: Chronomics -- 2.7 When to Eat -- 2.8 When to Treat -- References -- Chapter 3: Chronobioethics: What Is Life? -- 3.1 Encounters -- 3.2 Opportunities Enjoyed and Yet to Be Followed Up On -- 3.3 So What? -- 3.4 Maps -- 3.5 Conclusion -- 3.6 Epilogue -- References -- Chapter 4: Chronobiology -- 4.1 Introduction -- 4.2 Rhythms of Different Orders -- 4.3 Circadian and Extracircadian Oscillations in Heart Rate -- 4.3.1 The Cardiac Cycle -- 4.3.2 Respiratory Sinus Arrhythmia -- 4.3.3 REM/NREM Cycle -- 4.3.4 Other Ultradian Components -- 4.3.5 Circadians Chronoastrobiology -- 1994 -- 1995 -- 1996 -- 1998 -- 1999 -- 2000 -- 2001 -- 2002 -- 2003 -- 2004 -- 2005 -- 2006 -- 2009 -- 2010 -- 2011 -- 2012 -- 2013 -- 2014 -- Vascular Variability Syndromes -- 1990 -- 1991 -- 1992 -- 1993 -- 1994 -- 1995 -- 1996 -- 1997 -- 1998 -- 1999 -- 2000 -- 2001 -- 2002 -- 2003 -- 2004 -- 2005 -- 2006 -- 2007 -- 2008 -- 2010 -- 2011 -- 2012 -- 2013 -- 2014 -- Contents -- Chapter 1: From Chronobiology to Chronomedicine: Early Days -- 1.1 From Chronobiology to a Unified Science -- 1.2 Variability: Foe in 1948-1949, Friend Thereafter This book applies chronomics to the treatment of hypertension, covering analytic techniques and community-based assessments. Describes use of 7-day/24-h records of blood pressure to find masked hypertension, masked morning surge and other rhythm abnormalities