Chromatin (Springer Series in Molecular and Cell Biology)

Contemporary views on the structure and function of chromatin are presented and the history of the development of these ideas as well as the nature of the nucleic acid and protein components of chromatin are reviewed. The structure of chromatin is studied at several levels, and its modes of transcription and replication are analyzed. __Chromatin__ provides researchers with a critical evaluation of current knowledge. It combines much information that has never before been assembled, and evaluates and interrelates it in a critical way. This has not been done before so that readers are not only provided with an overview, but with extensive references to the literature (there are about 2000 references in all). Front Matter....Pages i-xii The First Hundred Years....Pages 1-15 Development of the Nucleosome Model for Chromatin Structure....Pages 16-30 The Structures of DNA....Pages 31-68 The Proteins of Chromatin. I. Histones....Pages 69-180 The Proteins of Chromatin. II. Nonhistone Chromosomal Proteins....Pages 181-218 The Nucleosome....Pages 219-288 Higher-Order Structure....Pages 289-354 Chromatin Structure and Transcription....Pages 355-408 Replication of Chromatin....Pages 409-431 Back Matter....Pages 432-497