کندرویتین سولفات: ساختار، نقش و فعالیت دارویی (پیشرفت‌ها در داروشناسی، جلد ۵۳)

CS is an unbranched, polydisperse, complex glycosaminoglycan extracted and purified from various tissues. This polyanion is interacting with both plasma and cells, it is able to modulate many biochemical and physiologic processes. Due to the presence of sulfate groups in different amounts and located in various positions, CS represents a very heterogeneous family of polysaccharides. therefore, the preparative approach and the analytical techniques are of paramount importance to produce CS with specific structure and properties and of pharmaceutical grade. *Includes recent technologies and methodologies to study and understand the structure and properties of chondroitin sulfate (CS) *Authoritative contributors from the scientific community with expertise in the field of CS and complex polysaccharides *Detailed and accurate figures to describe and illustrate complex molecular and macromolecular structures and properties Content: Isolation, Purification, and Analysis of Chondroitin Sulfate Proteoglycans Review Article Pages 3-20 Fumiko Matsui, Atsuhiko Oohira Isolation and Purification of Chondroitin Sulfate Review Article Pages 21-31 Luiz‐Claudio F. Silva Structure of Chondroitin Sulfate Review Article Pages 33-48 Fotini N. Lamari, Nikos K. Karamanos Progress in the Structural Biology of Chondroitin Sulfate Review Article Pages 49-67 Barbara Mulloy The Biosynthesis and Catabolism of Galactosaminoglycans Review Article Pages 69-115 Vikas Prabhakar, Ram Sasisekharan Biosynthesis of Chondroitin Sulfate: From the Early, Precursor Discoveries to Nowadays, Genetics Approaches Review Article Pages 117-140 Mauro S.G. Pavão, Ana Cristina Vilela‐Silva, Paulo A.S. Mourão Advances in the Analysis of Chondroitin/Dermatan Sulfate Review Article Pages 141-166 M. Stylianou, I.‐E. Triantaphyllidou, D.H. Vynios Chondroitin Sulfate Lyases: Applications in Analysis and Glycobiology Review Article Pages 167-186 Emmanuel Petit, Cedric Delattre, Dulce Papy‐Garcia, Philippe Michaud CS Lyases: Structure, Activity, and Applications in Analysis and the Treatment of Diseases Review Article Pages 187-215 Robert J. Linhardt, Fikri Y. Avci, Toshihiko Toida, Yeong Shik Kim, Miroslaw Cygler Structure, Metabolism, and Tissue Roles of Chondroitin Sulfate Proteoglycans Review Article Pages 219-232 Christopher J. Handley, Tom Samiric, Mirna Z. Ilic Emergence and Structural Characteristics of Chondroitin Sulfates in the Animal Kingdom Review Article Pages 233-251 Lucia O. Sampaio, Helena B. Nader Role of the Sulfation Pattern of Chondroitin Sulfate in its Biological Activities and in the Binding of Growth Factors Review Article Pages 253-279 Chilkunda D. Nandini, Kazuyuki Sugahara Chondroitin Sulfate as a Key Molecule in the Development of Atherosclerosis and Cancer Progression Review Article Pages 281-295 A.D. Theocharis, I. Tsolakis, G.N. Tzanakakis, Nikos K. Karamanos Chondroitin Sulfate Proteoglycans in Tumor Progression Review Article Pages 297-321 Yanusz Wegrowski, François‐Xavier Maquart Chondroitin Sulfate Proteoglycans in the Brain Review Article Pages 323-336 Sachiko Aono, Atsuhiko Oohira Chondroitin/Dermatan Sulfates in the Central Nervous System: Their Structures and Functions in Health and Disease Review Article Pages 337-356 Uwe Rauch, Joachim Kappler Chondroitin Sulfate Proteoglycan and its Degradation Products in CNS Repair Review Article Pages 357-374 Asya Rolls, Michal Schwartz Role of Chondroitin‐4‐Sulfate in Pregnancy‐Associated Malaria Review Article Pages 375-400 D. Channe Gowda Immunological Activity of Chondroitin Sulfate Review Article Pages 403-415 Toshihiko Toida, Shinobu Sakai, Hiroshi Akiyama, Robert J. Linhardt Antioxidant Activity of Chondroitin Sulfate Review Article Pages 417-431 G.M. Campo, A. Avenoso, S. Campo, A.M. Ferlazzo, A. Calatroni Effects of Chondroitin Sulfate on the Cellular Metabolism Review Article Pages 433-447 N. Brandl, J. Holzmann, R. Schabus, M. Huettinger In Vitro Effects of Chondroitin Sulfate Review Article Pages 449-465 A. Fioravanti, G. Collodel Effect of Chondroitin Sulfate as Nutraceutical in Dogs with Arthropathies Review Article Pages 467-474 Britta Dobenecker Chondroitin Sulfate as a Structure‐Modifying Agent Review Article Pages 475-488 Daniel Uebelhart, Ruud Knols, Eling D de Bruin, Gust Verbruggen Chondroitin Sulfate in the Management of Erosive Osteoarthritis of the Interphalangeal Finger Joints Review Article Pages 491-505 Gust Verbruggen Chondroitin Sulfate in the Management of Hip and Knee Osteoarthritis: An Overview Review Article Pages 507-522 Géraldine Bana, Bénédicte Jamard, Evelyne Verrouil, Bernard Mazières Treatment of Knee Osteoarthritis with Oral Chondroitin Sulfate Review Article Pages 523-539 Daniel Uebelhart, Ruud Knols, Eling D de Bruin, Gust Verbruggen Series Editors Page II Contents Pages V-XIV Abbreviations Pages XV-XVII Contributors Pages XIX-XXIII Preface Pages XXV-XXVI Index Pages 541-553 Contents of Previous Volumes Pages 555-568