Cholesterol Transporters of the START Domain Protein Family in Health and Disease [recurso electrónico] START Proteins - Structure and Function

Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis. This is an exciting new direction in the field and the purpose of this book will be to highlight the current research directed at potential roles for the START family in diabetes, cancer, and atherogenesis. This book also provides a personal and historical perspective of the discovery-to-publication journey that the authors had for their particular START domain family member. The goal will be to provide perspectives to graduate students, post-doctoral fellows, and endocrinology fellows on the research discovery process Front Matter....Pages i-xiv An Introduction to the Steroidogenic Acute Regulatory Protein (StAR)-Related Lipid Transfer Domain Protein Family....Pages 1-14 The Steroidogenic Acute Regulatory Protein (StAR)....Pages 15-47 START Domain Protein Structure and Ligand Specificity....Pages 49-72 Congenital Lipoid Adrenal Hyperplasia....Pages 73-97 Steroidogenic Acute Regulatory Protein (StAR) and Atherogenesis....Pages 99-117 STARD3: A Lipid Transfer Protein in Breast Cancer and Cholesterol Trafficking....Pages 119-138 The STARD4 Subfamily: STARD4 and STARD5 in Cholesterol Metabolism....Pages 139-171 Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Proteins in Non-vesicular Cholesterol Transport....Pages 173-188 Back Matter....Pages 189-190