Chemotherapy of Parasitic Diseases

"Have a chew of dulie," said Crubog . . . "What is it?" asked Potter, half-suspiciously. "Seaweed. " "Is it good for the virility? . . . " "And what is the virility?" asked the old man. "Does it make you more attractive to women?" Potier shouted in his ear. "No. " "What is it good for then?" "WortnS. " "Worms?" "Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. " "If it's an anthelmintic, I'll try a spot of it," said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has largely been broken down. By chemotherapy we now mean simply the treatment of disease by drugs (the word medicines has unhappily been eclipsed). The distinction made between chemotherapy and non­ chemical therapy (e. g. , radiation, physiotherapy, surgical intervention, immu­ nomodulation) remains useful despite some minor overlapping. The present work thus deals with drugs and their use in parasitic disease. (Since we are dealing with the treatment of incipient as well as established infection, chemotherapy subsumes chem­ oprophylaxis as well as chemotherapeusis per se. ) Definition of parasitism as a biological modus vivendi, although important in itself, need not concern us here. We need simply delimit the scope of the book, and that is easily done. Front Matter....Pages i-xxviii Front Matter....Pages 1-1 Historical Introduction....Pages 3-21 Front Matter....Pages 23-23 Chemistry of Antiprotozoal Agents....Pages 25-85 Protozoan Infections of Man: Malaria....Pages 87-114 Protozoan Infections of Man: American Trypanosomiasis and Leishmaniasis....Pages 115-127 Protozoan Infections of Man: African Trypanosomiasis....Pages 129-137 Protozoan Infections of Man: Other Infections....Pages 139-158 Protozoan Infections of Domestic Animals: Coccidian and Related Infections....Pages 159-170 Hemoprotozoan Infections of Domestic Animals: Trypanosomiasis, Babesiosis, Theileriosis, and Anaplasmosis....Pages 171-191 Modes of Action of Antiprotozoal Agents....Pages 193-207 Drug Resistance in Protozoa....Pages 209-236 Front Matter....Pages 237-237 Chemistry of Antinematodal Agents....Pages 239-266 Nematode Infections of Man: Intestinal Infections....Pages 267-276 Nematode Infections of Man: Extraintestinal Infections....Pages 277-286 Nematode Infections of Domestic Animals: Gastrointestinal Infections....Pages 287-305 Nematode Infections of Domestic Animals: Extraintestinal Infections....Pages 307-319 Mode of Action of Antinematodal Drugs....Pages 321-337 Drug Resistance in Nematodes....Pages 339-362 Front Matter....Pages 363-363 Chemistry of Antitrematodal Agents....Pages 365-383 Trematode Infections of Man....Pages 385-399 Trematode Infections of Domestic Animals....Pages 401-425 Front Matter....Pages 363-363 Mode of Action of Antitrematodal Agents....Pages 427-443 Front Matter....Pages 445-445 Chemistry of Anticestodal Agents....Pages 447-456 Cestode Infections of Man....Pages 457-477 Cestode Infections of Domestic Animals....Pages 479-494 Mode of Action of Anticestodal Agents....Pages 495-503 Front Matter....Pages 505-505 Chemistry of Drugs Used against Arthropod Parasites....Pages 507-529 Insect Infestations of Man....Pages 531-540 Acarine Infestations of Man....Pages 541-550 Insect Infestations of Domestic Animals....Pages 551-566 Acarine Infestation of Domestic Animals....Pages 567-583 Mode of Action of Agents Used against Arthropod Parasites....Pages 585-601 Drug Resistance in Arthropod Parasites....Pages 603-620 Back Matter....Pages 621-655