Chemotherapy and Pharmacology for Leukemia in Pregnancy: Guidelines and Strategies for Best Practices

In response to the complexity involved in treating leukemia during pregnancy, and the need to find the most efficient treatment possible without harming the fetus, this book offers essential guidelines for institutions and practitioners alike. Pursuing a comprehensive approach, the book addresses a broad range of subjects, including: pregnancy and its characteristics; staging, pathology, morbidity and what to expect in each type of leukemia; chemotherapy for leukemia in pregnant women with complete trials; dose adjustment of chemotherapy for leukemia in pregnancy based on serum dosages; and pharmacokinetics and pharmacodynamics for this unique group of patients. In turn, subsequent chapters focus on protecting the fetus and neonatal management regarding chemotherapy for leukemia in pregnancy, including the treatment and risks for the fetus (for each type of leukemia), intrathecal therapy and its effects on the fetus; supportive drugs, antibiotics and antifungals for pregnant patients during chemotherapy, including intervention and dose adjustments; palliative care for women with leukemia in pregnancy; breastfeeding during treatment for leukemia; pharmacological aspects of supplements, vitamins and nutrition in pregnancy during leukemia treatment; and more. Combining contributions from highly qualified hematology professionals, who have pooled their knowledge to address the treatment of virtually every aspect of leukemia in pregnancy, the book is aimed at a complete pharmacological treatment, including guidelines and trials. It is a must-have not only for institutions providing care for hematology patients, but also for residency programs, research institutions, and professionals in areas that involve leukemia treatment for pregnant women — e.g. hematology, neonatology, obstetrics clinics, intensive medicine and critical care units. Front Matter ....Pages i-x Introduction (Gustavo Alves)....Pages 1-21 Clinical Perspectives for Leukemia Treatment During Pregnancy (Giancarlo Fatobene, Ana Costa Cordeiro, Maria Cecília Borges Bittencourt, Rafael Fernandes Pessoa Mendes)....Pages 23-48 Chemotherapy Protocols for Leukemia During Pregnancy (Kaléu Mormino Otoni, Karla Bruna Nogueira Torres Mormino, Ranieri Sales de Souza Santos, Aline Rebeca de Sousa Magalhães)....Pages 49-75 Pharmacokinetics and Pharmacodynamics of Chemotherapy for Leukemia in Pregnancy (William Rotea Jr.)....Pages 77-93 Clinical Care of the Fetus and the Mother: Obstetrics Management for Patients on Treatment for Leukemia (Gilmar de Souza Osmundo Junior, Ana Maria Kondo Igai, Rossana Pulcineli Vieira Francisco)....Pages 95-104 Antibiotic and Antifungal Therapies During Leukemia Treatment in Pregnancy (Bruno Azevedo Randi, Vinicius Ponzio da Silva)....Pages 105-120 Transfusion in Pregnant Patients Receiving Treatment for Leukemia (Mariângela Borges Ribeiro da Silva)....Pages 121-137 Dose Adjustment of Chemotherapy for Leukemia in Pregnancy Based on Serum Dosages (Karla Rodrigues Andrade, Danilo Belchior Ponciano)....Pages 139-143 Supportive Drugs in Leukemia Treatment During Pregnancy (Celina de Jesus Guimarães, Sarah Sant’ Anna Maranhão, Pedro Mikael da Silva Costa, Claudia Pessoa)....Pages 145-179 Breastfeeding During Chemotherapy Treatment for Leukemia (Carolina Witchmichen Penteado Schmidt)....Pages 181-193 Palliative Care for Patients with Leukemia During Pregnancy (Andrea Maria Novaes Machado, Polianna Mara Rodrigues de Souza)....Pages 195-201 Back Matter ....Pages 203-210