Chemoselective and bioorthogonal ligation reactions. volume 1 and 2 : concepts and applications

This Timely, One-stop Reference Is The First On An Emerging And Interdisciplinary Topic. Covering Both Established And Recently Developed Ligation Chemistries, The Book Is Divided Into Two Didactic Parts: A Section That Focuses On The Details Of Bioorthogonal And Chemoselective Ligation Reactions At The Level Of Fundamental Organic Chemistry, And A Section That Focuses On Applications, Particularly In The Areas Of Chemical Biology, Biomaterials, And Bioanalysis, Highlighting The Capabilities And Benefits Of The Ligation Reactions. With Chapters Authored By Outstanding Scientists Who Range From Trailblazers In The Field To Young And Emerging Leaders, This Book On A Highly Interdisciplinary Topic Will Be Of Great Interest For Biochemists, Biologists, Materials Scientists, Pharmaceutical Chemists, Organic Chemists, And Many Others. Chemistries. A Brief Introduction To Traditional Bioconjugate Chemistry / W Russ Algar -- [3+2]-dipolar Cycloadditions In Bioconjugation / Jason E Hein -- Diels-alder And Inverse Diels-alder Reactions / Roberto J Brea, Neal K Devaraj -- The Staudinger Ligation / Olaia Nieto-garcía, Marcie B Jaffee, Michaela Mühlberg, Christian P R Hackenberger -- Thiol-ene Chemistry / Neil B Cramer, Christopher N Bowman -- Ligand-directed Tosyl And Acyl Imidazole Chemistry / Kazuya Matsuo, Itaru Hamachi -- Bioorthogonal Labeling Of Cellular Proteins By Enzymatic And Related Mechanisms / Scott A Walper, Kendrick B Turner, Igor L Medintz -- Metal-mediated Bioconjugation / Justin M Chalker -- Front Matter -- Applications. Protein And Antibody Labeling / Angela M Mariani, Kim E Sapsford -- Activity-based Protein Profiling / Eliane V Wolf, Steven H L Verhelst -- Nucleic Acid Labeling, Ligation, And Modification / Afaf H El-sagheer, Tom Brown -- Chemoselective Reactions For Glycan Labeling / Janet E Mccombs, Jennifer J Kohler -- Chemoselective Attachment Of Lipids To Proteins / Christian F W Becker -- In Vivo Applications Of Bioorthogonal Chemistries / Chelsea G Gordon, Carolyn R Bertozzi -- Immobilization Of Biomolecular Probes For Arrays And Assay: Critical Aspects Of Biointerfaces / Stella H North, Chris Rowe Taitt -- Chemical Ligations In The Design Of Hydrogel Materials / Scott H Medina, Joel P Schneider -- Nanoparticle Bioconjugates: Materials That Benefit From Chemoselective And Bioorthogonal Ligation Chemistries / Melissa Massey, W Russ Algar -- Application Of Engineered Viral Nanoparticles In Materials And Medicine / Michael D Glidden, John F Edelbrock, Amy M Wen, Sourabh Shukla, Yingfang Ma, Roger H French, Jonathan K Pokorski, Nicole F Steinmetz. Edited By W. Russ Algar, Philip E. Dawson And Igor L. Medintz. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Content: Contents to Volume 1 List of Contributors xi Preface xvii Part I Chemistries 1 1 A Brief Introduction to Traditional Bioconjugate Chemisrty 3W. Russ Algar 2 (3+2)-Doplar Cycloadditions in Bioconjugation 37Jason E. Hein 3 Diels-Adler and Inverse Diels-Adler Reactions 67Roberto J. Brea and Neal K. Devaraj 4 The Straudinger Ligation 97Olaia Nieto-Garcia, Marcie B. Jaffee, Michaela Muhlberg, and Christian P.R. Hackenberger 5 Thiol-Ene Chemistry 117Neil B. Cramer and Christopher N. Bowman 6 Ligand-Directed Tosyl and Acyl Imidazole Chemisrty 147Kazuya Matsuo and Itaru Hamachi 7 Bioorthogonal Labeling of Cellular Proteins by Enzymatic and Related Mechanisms 165Scott A. Walper, Kendrick B. Turner, and Igor L. Medintz 8 Metal-Mediated Bioconjugation 231Justin M. Chalker Contents to Volume 2 List of Contributors xiii Preface xix Part II applications 271 9 Protein and Anitbody Labeling 273Angela M. Mariani and Kim E. Sapsford 10 Activity-Based Protein Profiling 305Elaine V. Wolf and Steven H.L. Verhelst 11 Nucleic Acid Labeling, Ligation and Modicfication 335Afah H. El-Sagheer and Tom Brown 12 Chemoselective Reactions for Glycan Labeling 363Janet E. McCombs and Jennifer J. Kholer 13 Chemoselective Attachment of Lipids to Proteins 391Christian F. W. Becker 14 In Vivo Applications of Bioorthogonal Chemistries 417Chelsea G. Gordon and Carolyn R. Bertozzi 15 Immobilization of Biomolecular Probes for Arrays and Assays: Critical Aspects of Biointerfaces 459Stella H. North and Chris Rowe Taitt 16 Chemical Ligations in the Design of Hydrogel Materials 497Scott H. Medina and Joel P. Schneider 17 Nanoparticle Bioconjugates: Materials that Benefit from Chemoselective and Bioorthogonal Ligation Chemistires 543Melissa Massey and W. Russ Algar 18 Applications of Engineered Viral Nanoparticles in Materials and Medicine 631Michael D. Glidden II, John F. Edelbrock, Amy M. Wen, Sourabh Shukla, Yingfang Ma, Roger H. French, Jonathan K. Pokorski, and Nicole F. Steinmetz Index 711 Part IChemistries ;A brief introduction to traditional bioconjugate chemistry /W. Russ Algar --[3+2]-dipolar cycloadditions in bioconjugation /Jason E. Hein --Diels-Alder and inverse Diels-Alder reactions /Roberto J. Brea and Neal K. Devaraj --The Staudinger ligation /Olaia Nieto-García, Marcie B. Jaffee, Michaela Mühlberg, Christian P.R. Hackenberger --Thiol-ene chemistry /Neil B. Cramer and Christopher N. Bowman --Ligand-directed tosyl and acyl imidazole chemistry /Kazuya Matsuo and Itaru Hamachi --Bioorthogonal labeling of cellular proteins by enzymatic and related mechanisms /Scott A. Walper, Kendrick B. Turner and Igor L. Medintz --Metal-mediated bioconjugation /Justin M. Chalker --Volume 2, Part IIApplications ; Protein and antibody labeling /Angela M. Mariani and Kim E. Sapsford --Activity-based protein profiling /Eliane V. Wolf and Steven H.L. Verhelst --Nucleic acid labeling, ligation, and modification /Afaf H. El-Sagheer and Tom Brown --Chemoselective reactions for glycan labeling /Janet E. McCombs and Jennifer J. Kohler --Chemoselective attachment of lipids to proteins /Christian F.W. Becker --In vivo applications of bioorthogonal chemistries /Chelsea G. Gordon and Carolyn R. Bertozzi --Immobilization of biomolecular probes for arrays and assay : critical aspects of biointerfaces /Stella H. North and Chris Rowe Taitt --Chemical ligations in the design of hydrogel materials /Scott H. Medina and Joel P. Schneider --Nanoparticle bioconjugates : materials that benefit from chemoselective and bioorthogonal ligation chemistries /Melissa Massey and W. Russ Algar --Application of engineered viral nanoparticles in materials and medicine /Michael D. Glidden II, John F. Edelbrock, Amy M. Wen, Sourabh Shukla, Yingfang Ma, Roger H. French, Jonathan K. Pokorski, Nicole F. Steinmetz

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

This timely two-volume reference is the first on this emerging and interdisciplinary topic, covering everything from methods to applications in bioorthogonal chemistry and chemical ligation reactions, focusing on both established as well as recently developed chemistries.