Chemokines in Disease: Biology and Clinical Research (Contemporary Immunology)

Caroline Hébert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases. Front Matter....Pages i-xx Front Matter....Pages 1-1 The Chemokine Gene Family....Pages 3-18 Novel Chemokines Identified in Expressed Sequence Tag Databases via Bioinformatics....Pages 19-39 Understanding Chemokine Biology Through Mouse Genetics....Pages 41-51 MCP-1 in Human Disease....Pages 53-65 Front Matter....Pages 67-67 IL-8 in Animal Models of Disease....Pages 69-80 The Role of Chemokines in the Pathophysiology of the Acute Respiratory Distress Syndrome (ARDS)....Pages 81-110 The Role of Chemokines in Allergic Airway Inflammation....Pages 111-121 Eotaxin in Disease....Pages 123-138 The Role of CC Chemokines in Th1- and Th2-Type Pulmonary Inflammation Models....Pages 139-149 Chemokines in Rheumatoid Arthritis....Pages 151-158 Potential Roles for Chemokines in Transplant Rejection....Pages 159-168 Front Matter....Pages 169-169 The Role of CXC Chemokines in the Regulation of Angiogenesis in Association with Non-Small-Cell Lung Cancer....Pages 171-189 The Role of ELR + -CXC Chemokines in Wound Healing and Melanoma Biology....Pages 191-214 Engineering, Biology, and Clinical Development of hMIP-1α....Pages 215-232 Front Matter....Pages 233-233 Viral Mimicry of Chemokines and Chemokine Receptors....Pages 235-251 The HIV Coreceptor Repertoire....Pages 253-268 HIV-1 Coreceptors and Viral Tropism....Pages 269-280 Mutation Analysis of Receptors and Relationship of Receptor Usage to Disease....Pages 281-294 Chemokines and Chemokine Receptors in the Brain....Pages 295-312 Antagonism of Chemokine Receptors in Preventing Infection by HIV....Pages 313-322 Back Matter....Pages 323-330 Caroline Hebert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. Our understanding of the function of chemokines has been reshaped over the past few years because of the large number of new chemokines recently discovered.