Chemistry of Opioids (Topics in Current Chemistry Book 299)

Recent Advances in the Synthesis of Morphine and Related Alkaloids; by N. Chida \* Opioids in Preclinical and Clinical Trials; by H. Nagase and H. Fujii \* Synthesis of 14-Alkoxymorphinan Derivatives and Their Pharmacological Actions; by H. Schmidhammer and M. Spetea \* 14-Amino-4,5-Epoxymorphinan Derivatives and Their Pharmacological Actions; by J. W. Lewis and S. M. Husbands \* Nonpeptidic Delta (δ) Opioid Agonists and Antagonists of the Diarylmethylpiperazine Class: What Have We Learned?; by S. N. Calderon \* Synthesis of Neoclerodane Diterpenes and Their Pharmacological Effects; by K. M. Lovell, K. M. Prevatt-Smith, A. Lozama and T. E. Prisinzano \* Synthesis of Novel Basic Skeletons Derived from Naltrexone; by H. Nagase and H. Fujii \* Twin and Triplet Drugs in Opioid Research; by H. Fujii \* 3D-Pharmacophore Identification for κ-Opioid Agonists Using Ligand-Based Drug-Design Techniques; by N. Yamaotsu and S. Hirono Front Matter....Pages i-xiii Recent Advances in the Synthesis of Morphine and Related Alkaloids....Pages 1-28 Opioids in Preclinical and Clinical Trials....Pages 29-62 Synthesis of 14-Alkoxymorphinan Derivatives and Their Pharmacological Actions....Pages 63-91 14-Amino-4,5-Epoxymorphinan Derivatives and Their Pharmacological Actions....Pages 93-119 Nonpeptidic Delta (δ) Opioid Agonists and Antagonists of the Diarylmethylpiperazine Class: What Have We Learned?....Pages 121-140 Synthesis of Neoclerodane Diterpenes and Their Pharmacological Effects....Pages 141-185 Synthesis of Novel Basic Skeletons Derived from Naltrexone....Pages 187-237 Twin and Triplet Drugs in Opioid Research....Pages 239-275 3D-Pharmacophore Identification for κ-Opioid Agonists Using Ligand-Based Drug-Design Techniques....Pages 277-307 Back Matter....Pages 309-312