Chemistry and Biology of Serpins (Advances in Experimental Medicine and Biology, 425)

**`**The editors have succeeded in producing a volume of work which provides many answers to questions, asked and unasked, about a critically important field of biologic research. It should be in the library of any scientist with an interest in human physiology; it would be useful to many other researchers as well.**'** **Chemtracts - Biochemistry and Molecular Biology, 12:10 (1999)** Front Matter....Pages i-xix Serpins....Pages 1-4 Serpins....Pages 5-15 Antithrombin....Pages 17-33 Heparin Cofactor II....Pages 35-44 PCI: Protein C Inhibitor?....Pages 45-54 Molecular Basis for the Resistance of Fibrin-Bound Thrombin to Inactivation by Heparin/Serpin Complexes....Pages 55-66 Regulation of Neurons and Astrocytes by Thrombin and Protease Nexin-1....Pages 67-75 Maspin....Pages 77-88 Proteases and Protease Inhibitors in Tumor Progression....Pages 89-97 The Role of Reactive-Center Loop Mobility in the Serpin Inhibitory Mechanism....Pages 99-108 Substrate Specificity of Tissue Type Plasminogen Activator....Pages 109-121 Plasminogen Activator Inhibitor Type-2....Pages 123-130 Of Mice and Men....Pages 131-141 Biology of Progesterone-Induced Uterine Serpins....Pages 143-154 Serpins from an Insect, Manduca sexta ....Pages 155-161 The Significance of Serpins in the Regulation of Proteases in the Male Genital Tract....Pages 163-176 Serpins and Programmed Cell Death....Pages 177-183 C1 Inhibitor....Pages 185-194 Serp-1, A Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection....Pages 195-205 Dysfunctional Variants and the Structural Biology of the Serpins....Pages 207-222 Structure-Function Studies on PEDF....Pages 223-237 Colligin, A Collagen Binding Serpin....Pages 239-245 Coagulation, Neurobiology, and Cancer....Pages 247-280 Fibrinolysis, Development, and Reproduction....Pages 281-305 Inflammation and Noninhibitor Serpins....Pages 307-339 Back Matter....Pages 341-358 ` The editors have succeeded in producing a volume of work which provides many answers to questions, asked and unasked, about a critically important field of biologic research. It should be in the library of any scientist with an interest in human physiology; it would be useful to many other researchers as well. ' Chemtracts - Biochemistry and Molecular Biology, 12:10 (1999) Proceedings of an International Symposium held in Chapel Hill, North Carolina, April 13-16, 1996