Chemistry and Biology of Pteridines : Pteridines and Folic Acid Derivatives. Proceedings of the International Symposium on Pteridines and Folic Acid Derivatives, Chemical, Biological and Clinical Aspects. 7, St. Andrews, Scotland, September 21-24, 1982

Die Reihe Studia Linguistica Germanica (SLG), 1968 von Ludwig Erich Schmitt und Stefan Sonderegger begründet, ist ein renommiertes Publikationsorgan der germanistischen Linguistik. Die Reihe verfolgt das Ziel, mit dem Schwerpunkt auf sprach- und wissenschaftshistorischen Fragestellungen die gesamte Bandbreite des Faches zu repräsentieren. Dazu zählen u. a. Arbeiten zur historischen Grammatik und Semantik des Deutschen, zum Verhältnis von Sprache und Kultur, zur Geschichte der Sprachtheorie, zur Dialektologie, Lexikologie/Lexikographie, Textlinguistik und zur Einbettung des Deutschen in den europäischen Sprachkontext. The Gowland Hopkins Lecture: Transport of Folate and Pterin Compounds Chemical Aspects (1) Scottish International Education Trust Lecture: Synthetic Methods in Pteridine Chemistry: Some Applications to Pteridine Natural Products Synthesis, Chemical and Enzymatic Properties, and Therapeutic Potential of 6, 6-Disubstituted Tetrahydro- and Quinoid-Dihydro-Pterins The Structure of Quinonoid Dihydropterins [2-Amino-7,8 (6H)-Dihydropteridin-4-ones] Some Simple s-Triazolopteridines Linear Tricyclic Analogs of Pteridines Reactions of Furazano [3, 4-d] Pyrimidines and their Application to Pteridine Synthesis Syntheses of some Blocked 7, 8-Dihydropteridines Synthesis of Chiral Reduced Pteridine Coenzymes Report on Discussions Chemical Aspects (2) Reactivity of Pteridines Synthesis and Antitumor Activity of 10-Deazaminopterins Synthesis and Biological Activity of 5-Deazafolic Acid and 5-Deazaaminopterin The Nor-Analogues of Folic Acid Report on Discussions Neurochemical and Clinical Aspects Metabolism of Pteridine Cofactors in Neurochemistry Pteridines in Cancer and Other Diseases Dihydropteridine Reductase Activity in Human Breast Cancer. Studies of 580 Cases and Correlations with Hormone Receptors and Cellular Typing A Critical Appraisal of Methods for the Quantitative Analysis of Tetrahydrobiopterin, Dihydrobiopterin and Biopterin in Human Urine, Serum and CSF Inhibition of Pterin Biosynthesis in the Adrenergic Neuroblastoma N1E115 by Tetrahydrobiopterin and Folate Penetration of Reduced Pterins into Rat Brain: Effect on Biogenic Amine Synthesis Neopterin Deficiency (GTP Cyclohydrolase I Deficiency), a New Variant of Hyperphenylalaninemia Folate Pathways in Cells from Fragile X Syndrome Patients and Carriers Report on Discussions Enzymology The Interaction of Substrates and Inhibitors with Dihydrofolate Reductase Catalytic Site of Dihydrofolate Reductase Structure, Function and Affinity Labelling Studies of Dihydrofolate Reductase Methylene Tetrahydrofolate Reductase: Studies in a Human Mutant and Mammalian Liver Studies on Methylenetetrahydrofolate Reductase from Pig Liver: Catalytic Mechanism and Regulation by Adenosylmethionine Role of Methylenetetrahydrofolic Acid Reductase in Regulation of Folic Acid Metabolism and its Relation to the Methyl Trap Hypothesis The Mechanism of Action of the Transformylase Enzymes Folypolyglutamate Synthesis in Neurospora Crassa Report on Discussions Clinical Aspects: Cancer Folates and Cancer Chemotherapy Inability to Increase the Mobilisation of Liver Folates During Folate Deficiency Suggesting that this and Other Organs do not act as a Potential Folate Store for Marrow and Other Rapidly Proliferating Cells A High Molecular Weight Nonfunctional Immunoreactive Form of Dihydrofolate Reductase in L1210 Leukaemia Cells Further Characterization of the Pterdine Binding Variant of Alpha1-Acid Glycoprotein, Accumulated in the Blood of Patients with Malignant Diseases Structure-Activity Relationships among 5-Substituted Lipophilic Diaminopyrimidine Antineoplastic Antifolates Attempts to Design Inhibitors of Dihydrofolate Reductase Using Interactive Computer Graphics with Real Time Energy Calculations Control of Methotrexate Polyglutamate Synthesis in Cultured Rat Hepatoma Cells Differential Effects of Methotrexate or Fluorodeoxyuridine upon Mitochondrial and Cellular Nucleotide Pools Report on Discussions Bioorganic Chemistry and Enzymology Chemical Mechanisms in the Action of Pteridine Coenzymes Irreversible Inactivation of Rat Liver Phenylalanine Hydroxylase by Reaction with (6S)-L-Erythro-Tetrahydro- biopterin p-Azidophenylalanine: A Potential Photoaffinity Probe for Rat-Liver Phenylalanine Hydroxylase Pyrimidine Models for the Cofactor of Phenylalanine Hydroxylase. Autoxidation of 2, 4, 5,-Triamino-6-Hydroxy- pyrimidines Activation of Molecular Oxygen by Tetrahydropterin Monooxygenases Mechanistic Studies on Phenylalanine Hydroxylase: Structural Determination of the Tetrahydropterin Intermediates Properties of Thymidylate Synthase from Streptococcus Faecium Cloning the Gene for Eukaryotic C1-THF Synthase Report on Discussions Biochemistry and Biology The Enzymatic Synthesis of the Drosopterins: Identification of a Pyrimidodiazepine as an Intermediate The Common Precursor of Sepiapterin and Drosopterin in Drosophila: Enzymatic and Chemical Synthesis The Role of Pteridines in Regulation of Growth The Regulation of Molybdenum Cofactor in Escherichia Còli Evidence for a Folate Bound to Rat Hepatic Uroporphyrinogen III Cosynthase and its Role in the Biosynthesis of Heme Report on Discussions Aerobic Oxidation of 5, 6, 7, 8-Tetrahydroneopterin The Conformations of 7, 8 (6H)-Dihydropterin Substrates and the Activity of Dihydropteridine Reductase (E.C. 1. 6. 99. 10) Dihydrofolate Reductase: The Stereochemistry of Inhibitor Selectivity Synthesis of an 8-Deaza Analog of the Intermediate in the Thymidylate Synthetase Reaction (1) The Synthesis of Analogs of Pteroylglatamyl-?-Phosphate as Potential Inhibitors of Folylpolyglutamate Synthetase Synthesis and Activity of 8, 1O-Dideazaminopterin CNDO/2 Molecular Orbital Calculations on the Antifolate DAMP and Some of its Analogues: Conformational Characteristics Fluorescent Analogues of Methotrexate as Probes for Folate Antagonist Molecular Receptors Dihydrofolate Reductase Overproduction Identified by Flow Cytometry Using a Fluorescent Methotrexate Analogue New Syntheses and Transformations of Some Pteridines and Pteridine 3-Oxides Photooxidation of Mercaptopteridines Reactivity of 6, 7-Dichloro-1, 3-Dimethyllumazine Synthesis, Reactivity and Properties of 8-Substituted 2-Thio- and 2,4-Dithiolumazines The Activity of Sulfonamide-Substituted Benzylpyrimidines Against Dihydropteroate Synthase, Dihydrofolate Reductase, and Bacterial Cell Cultures Structural Studies of Antifolate Drugs Isolation and Characterization of a Novel Folate Antagonist Synthesis and Biological Properties of the S-8 Analog of 7, 8-Dihydropteridinealcohol Synthesis of Dihydrobiopterin from Dihydroneopterin Triphosphate in Rat Tissues and Human Blood Corpuscles: Diagnosis of Atypical Phenylketonuria due to Biopterin Deficiency by Assay of an Enzyme Involved in the Synthesis Stereospecific Enzyme Mediated Syntheses of Tetrahydrofolate Derivatives Immobilization of Dihydrofolate Reductase from Amethopterin Resistant Lactobacillus Casei X-Ray Studies of the Binding of Trimethoprim, Methotrexate, Pyrimethamine and Two Trimethoprim Analogues to Bacterial Dihydrofolate Reductase A New Spectrophotometric Method for the Assessment of Tight Binding Benzyldiaminopyrimidine Inhibitors of Dihydrofolate Reductase Two Interconverting Conformers of a Drug-Receptor Complex: The Lactobacillus Casei Dihydrofolate Reductase-NADP+- Trimethoprim Complex Multiple Conformations of the Dihydrofolate Reductase- Folate-NADP+ Complex The Three-Dimensional Structure of Mouse L 1210 Dihydrofolate Reductase Isolation and Amino Acid Sequence Studies of Dihydrofolate Reductase from Neisseria Gonorrhoeae Purification of 7, 8-Dihydropteroate-Synthetase from E. Coli by Affinity- and Hydrophobic Interaction Chromatography Isolation and Characterization of an E. Coli Mutant Affected in Dihydrofolate- and Folylpolyglutamate- Synthetase Purification and Properties of 5-Formyltetrahydrofolate Cyclodehydrase from Rabbit Liver Structural Studies on Formyl-Methenyl-Methylene Tetra- hydrofolate Synthetase from Rabbit Liver Utilization of Folate Polyglutamate for Growth by Lactobacillus Casei Folate and Folate Enzymes as Structural Components of Bacteriophage Particles Studies on the Substrate Specificity of Mammalian Folylpolyglutamate Synthetase Properties of Corynebacterium Species Dihydrofolate Synthetase-Folylpolyglutamate Synthetase Purification and Characterization of Folylpolyglutamate Synthetase from Lactobacillus Casei and Hog Liver The Molybdenum Cofactor from Xanthine Oxidase: Quantitative Assay of the Molybdenum Cofactor by Activation of Nitrate Reductase Activity in Extracts of the Nit-1 Mutant of Neurospora crassa Structural Studies of Calf Thymus Thymidylate Synthase A Comparison of the T-Even Phage Induced and Escherichia Coli Thymidylate Synthases Thermophilicity of Dihydrofolate Reductase and Thymidylate Synthetase from a Thermophilic Microorganism Chemical Characterization of Two Folate-Binding Proteins from Mitochondria: Dimethylglycine Dehydrogenase and Sarcosine Dehydrogenase Allosteric Mung Bean (Vigna radiata) Serine HydroxyLmethy1-Transferase Comparative Study of the Eye Colour Mutants of Drosophila Melanogaster: Quantification of the Eye-Pigments and Related Metabolites Studies on Sepialumazine, the Characteristic Larval Integument Pigment of the Bombyx Mori Kiuki Mutant Macromolecular Regulation of Sepiapterin and Drosopterin Synthesis in the Purple Mutant of Drosophila The Hydroxylation of Phenylpropanoids by Euglena gracilis : Role of Pteridines Studies with Old Yellow Enzyme, Reconstitution with Lumazine Analogs as Coenzyme Biosynthesis of Riboflavin. Origin of the Xylene Ring Biosynthesis of Riboflavin. Synthesis of the Substrate and of Substrate Analogues for Pyrimidine Deaminase Metabolism and Function of Pterin Compounds in Seed Germination Thymidylate Synthetase During Proliferation and Differentiation of Physarum polycephalum Influence of Vitamin B12 on Folate Metabolism in Lactobacillus leichmannii High-Affinity Binding of Folate to a Small and Large Molecular Size Protein from Human Milk High-Affinity Folate Binding in Leukocytes from Normal Subjects Displays Positive Cooperativity, and the Affinity Depends on the Protein Concentration Characteristics of 5-Methyltetrahydrofolate Binding to the Folate-Binding Protein from Cow’s Whey Interactions of Folate-Dependent Enzymes of DNA Precursor Metabolism in T4 Phage-Infected Bacteria The Regulation of Biopterin Biosynthesis in the Rat Biosynthesis of Tetrahydrobiopterin in Mammalian Tissues by De Novo and Salvage Pathways Perspectives on Tetrahydrobiopterin Biosynthesis in Mammals Human Dihydropteridine Reductase (DHPR) Deficiency Coordinate Regulation of Guanosine Triphosphate Cyclo- hydrolase and Tetrahydrobiopterin in Adrenal Medullary Chromaffin Cells Regulation of Adrenocortical Guanosine Triphosphate Cyclohydrolase and Tetrahydrobiopterin in Normal and Spontaneously Hypertensive Rats Inhibition of Brain Sepiapterin Reductase by a Catecholamine and an Indoleamine Mouse Mastocytoma Tryptophan Hydroxylase: Role of Iron and Catalase in the Expression of Enzyme Activity after Activation by Anaerobic Preincubation with Dithiothreitol Folic Acid Induced Kindling in Rats: Changes in Brain Amino Acids Impaired Pteroylpolyglutamate Synthesis in the Cobalamin-Inactivated Rat A Radioimmunoassay for Determination of D-Erythro- Neopterin Radioimmunoassay for Neopterin in Body Fluid and Tissues A Specific Antiserum Against Tetrahydrobiopterin: Its Preparation and Application to Immunohistochemistry Speculation on the Mechanism of Therapeutic Action of Tetrahydrobiopterin in Human Disease Correlation of Tetrahydrobiopterin Content and Guanosine Triphosphate Cyclohydrolase Activity in Cells and Tissues Unconjugated Pteridines in Human Physiological Fluids. Normal and Pathological Profiles Biopterin and Phenylalanine Metabolism During Early Liver Regeneration GTP-Cyclohydrolase Activities in Rat Liver Phenylalanine Hydroxylase Assay Using Biopterin and Synthetic Pteridine Dihydropteridine Reductase Levels in Human Normal and Neoplastic Tissues Investigations of Tissue Folates in Normal and Malignant Tissues Blood Cell Biopterin as an Indicator of Transplanation- Induced Hemopoiesis and Leukemic Cell Proliferation Assessment of Urinary Neopterin in the Early Diagnosis of Human Allograft Rejection Behaviour of Neopterin Levels in Patients with Haematological and Gynaecological Neoplasms Pteridines in Dictyostelium discoideum and Physarum polycephalum Biochemical and Chemotherapy Studies on BW 301U, a Novel Lipophilic 2, 4-Diaminopyridopyrimidine Antifolate Toxicity of a Series of Antifolate Compounds in a Methotrexate-Resistant Cell Line Interaction of Methotrexate Poly (L-Lysine) with Transformed Hepatic Cells in Culture A Novel Technique for Producing Folate-Deficient Hepatica Cells Methotrexate Metabolism in Acute Lymphoblastic Leukemia Altered Methotrexate Sensitivity in Human Leukemic K562 Amino Acid Transport Mutant Cells Methotrexate and Methotrexate Polyglutamates in Erythrocytes After High-Dose Methotrexate Methotrexate Polyglutamates in Human Fibroblasts: Reversal of Antifolate Cytotoxicity Human Cells Resistant to Methotrexate: Cross Resistance and Collateral Sensitivity to the Nonclassical Antifolates Trimetrexate, Metoprine, Homofolic Acid and CB3 717 Homology of Two Forms of Dihydrofolate Reductase in Human Leukaemic and L1210 Cells During Expression of Resistance to Methotrexate Adaptation of Folylpolyglutamates to Folate Deprivation in Mouse Hepatoma Cells Utilization and Loss of Reduced Folates by Human Fibroblasts in Vitro Factors Affecting Folate Polyglutamate Biosynthesis in Rat Liver Differential Binding of Folates but not Methotrexate (MTX) by Brush Border (BB) and Basal Lateral (BL) Membranes of Rat Renal Cortex Biosynthesis of Folate Derivatives in Ehrlich Ascites Carcinoma Cells Grown in Mice and in some Organs of the Host Variability of Thymidylate Synthetase in Ehrlich Carcinoma Cells and its Role in Resistance to 5-Fluorodeoxyuridine One-Carbon Metabolism in Human Lymphocytes Possible Mechanisms of Folate Catabolism The Intracellular Folate Pool: Studies of Kinetics and Functional Significance Intestinal Folate Transport. A pH-Dependent, Carrier- Mediated Process Effects of Folate Depletion on Growth and Survival of Human Cell Line K-562 in Culture Alterations in Folate Metabolism of the Rat Induced by Acute Ethanol Administration Participation of Pterins in the Control of Lymphocyte Transformation and Lymphoblast Proliferation The Pterin Component of the Molybdenum Cofactor (Molybdopterin): Relationship to Urothione Report on Presented Papers Author Index Subject Index