Chemical Factors in Hypertension: A collection of papers and discussion presented at the Symposium on Chemical Factors in Hypertension - 115th Ntl. Mtg. San Francisco, March 28 to April 1, 1949 (Advances in Chemistry Series)

Title......Page 1 Copyright......Page 2 FOREWORD......Page 3 Role of Adrenergic Blockade......Page 4 Humoral Pressor Substances and Their Relation to Arterial Hypertension......Page 6 Effects of Psychic Disturbances......Page 7 Table I . Pressor Substances Possibly Related to Hypertension*......Page 8 Nephrogenic Protein Pressor Substances......Page 9 Figure 2. Oxygen Uptake by Amine Oxidase Preparations and Tyramine, Hypertensin (Angiotonin), and Histamine......Page 10 Peptide Pressor Agents......Page 12 Amine Pressor Substances......Page 13 Substances Probably of Amine Nature......Page 15 Table III . Pressor Activity of Aminelike Compounds in the Rat......Page 16 Amine Oxidase and Amines......Page 17 Nicotine Bases......Page 18 Adrenal Cortical Hormones......Page 19 Figure 3. Effect of Intravenously Administered Amine Oxidase on Blood Pressure and Blood Urea Nitrogen of Hypertensive Dogs......Page 20 Figure 4. Prevention of Pressor Action of Renin and Hypertensin (Angiotonin) by Amine Oxidase......Page 21 Figure 5. Prevention of Pressor Action of Renin and Hypertensin by Amine Oxidase......Page 22 Summary and Conclusions......Page 23 Literature Cited......Page 24 Discussion of Paper on Humoral Pressor Substances and Their Relation to Arterial Hypertension......Page 25 Neurogenic Hypertension......Page 27 Table I . Cardiovascular Characteristics of Various Types of Hypertension......Page 28 Renal Hypertension......Page 29 Factors in Blood Pressure Regulation......Page 30 Sympatho-adrenal Factors in Development of Hypertension......Page 31 Figure 2. Possible Contributions to Maintenance of Systemic Arterial Pressure during Neurogenic Hypertension......Page 32 Adrenergic Blocking Agents......Page 33 Figure 3. Possible Contributions to Maintenance of Systemic Arterial Pressure during Renal (and Perhaps Essential) Hypertension......Page 34 Ergot Alkaloids......Page 35 Summary......Page 36 Literature Cited......Page 37 Discussion of Paper on Role of Sympathetic Blockade in the Therapy of Hypertension......Page 39 Biosynthesis and Metabolism of Phenylethyl (Pressor) Amines......Page 40 Figure 1. Effect of Unpleasant Interview on Cardiac Stroke Vol ­ ume, Blood Pressure, Renal Blood Flow, Filtration Fraction, and Urine Flow of Patient......Page 41 Figure 2. Effect of Reassurance and Sedation on Blood Pressure and Renal Functions of Hypertensive Patient......Page 42 Figure 3. Effect of Hepatic Nerve Stimulation......Page 43 Synthesis of Pressor Amines......Page 44 Table 1. Alternative Schemes for Synthesis......Page 45 Figure 4. Blood Pressure Records from Anesthetized Cat before and following Administration of Adrenolytic Agent......Page 46 Figure 5. Anaerobic Decarboxylation......Page 47 Figure 6. Inhibitory Effect of Amines......Page 48 Figure 7. Pressor Response in Anesthetized Cat......Page 49 Figure 8. Blood Pressure Response......Page 50 Elimination and Inactivation of Pressor Amines......Page 51 Figure 9. Blood Pressure Response to Unclampîng of Opposite Kidney......Page 52 Figure 10. Pressor Response to Intravenous Injection......Page 53 Figure 11. Effect of Intravenously Injected Phenylserine......Page 54 Figure 12. Effect of Intravenously Injected /-Epinephrine,......Page 55 Comment......Page 56 Bibliography......Page 57 Discussion of Paper on Biosynthesis and Metabolism of Phenylethyl (Pressor) Amines......Page 60 Literature Cited......Page 61