Chemical carcinogenesis [proceedings of a NATO Advanced Study Institute, which was the second course of the International School of Pure and Applied Biostructure, held October 18-30, 1981, at the Ettore Majorana Center for Scientific Culture, Erice, Italy

During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino­ genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob­ vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino­ genesis. The course had this as its major objective and the re­ sulting book does reflect it. Front Matter....Pages i-ix Front Matter....Pages xi-xi Chemical Carcinogenesis by Polycyclic Aromatic Hydrocarbons....Pages 1-24 N-Substituted Aromatic Compounds....Pages 25-46 Metabolic Epoxidation of Aflatoxin B 1 and its Metabolites: Patterns of DNA Adduct Formation and Removal in Relation to Biological Effects....Pages 47-66 Problems Associated with the Use of Chemical Class Controls in Absence of Information on the Underlying Mechanism....Pages 67-70 Front Matter....Pages N3-N3 DNA Lesions : Nature and Genesis....Pages 75-92 DNA Alkaline Elution: Physical Basis of the Elution Process and Validation of this Method as a Screening Procedure to Identify Chemical Carcinogens....Pages 93-119 DNA Fragmentation: Its Predictivity as a Short Term Test....Pages 121-154 Measurement of Viscous and Elastic Components of Native DNA Fiber Following Carcinogen Administration....Pages 155-165 Initiation of Experimental Liver Carcinogenesis by Chemicals: Are the Carcinogen Altered Hepatocytes Stimulated to Grow into Foci by Different Selection Procedures Identical?....Pages 167-178 Influence of DNA Conformation on DNA Methylation and the Direct Binding of N-Methyl-N-Nitroso-N 1 -Nitroguanidine....Pages 179-191 Genotoxic Effects of Drugs: Experimental Findings Concerning Some Chemical Families of Therapeutic Relevance....Pages 193-221 Front Matter....Pages N5-N5 Phenobarbital and other Liver Tumor Promoters....Pages 231-260 Molecular Mechanisms of Multistage Carcinogenesis....Pages 261-278 Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine....Pages 279-288 Front Matter....Pages N7-N7 Some Critical Consideration Concerning Sequential Analysis of Carcinogenesis with Chemicals....Pages 295-313 Benign and Malignant Tumor Induction in Mouse Skin....Pages 315-345 Progress in the Study of in Vitro Neoplastic Transformation....Pages 347-362 Pulse-Carcinogenesis by Ethylnitrosourea in the Developing Rat Nervous System: Molecular and Cellular Mechanisms....Pages 363-379 Chromatin, Nuclei and Water: Alterations and Mechanisms for Chemically- Induced Carcinogenesis....Pages 381-434 The Cytoskeleton: An Intermediate in the Expression of the Transformed Phenotype in Malignant Cells....Pages 435-467 Back Matter....Pages 480-492