Chemical Carcinogenesis and Mutagenesis I (Handbook of Experimental Pharmacology, 94 / 1)

I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin­ Madison. I immediately started to work with the carcinogenic aminoazo dyes un­ der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part­ nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi­ cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car­ cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re­ lated factors. Front Matter....Pages I-XXVIII Front Matter....Pages 1-1 Mechanisms of Chemical Carcinogenesis: Theoretical and Experimental Bases....Pages 3-29 Front Matter....Pages 31-31 Environmental Carcinogens....Pages 33-61 Advances in Tobacco Carcinogenesis....Pages 63-102 Occupational Carcinogens....Pages 103-151 Therapeutic Agents as Potential Carcinogens....Pages 153-175 Front Matter....Pages 177-177 In Vivo Testing for Carcinogenicity....Pages 179-209 Transformation of Cells in Culture....Pages 211-264 Front Matter....Pages 265-265 Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons....Pages 267-325 Polycyclic Aromatic Hydrocarbons: Metabolism, Activation and Tumour Initiation....Pages 327-372 Interactions of Fungal and Plant Toxins with DNA: Aflatoxins, Sterigmatocystin, Safrole, Cycasin, and Pyrrolizidine Alkaloids....Pages 373-407 N -Nitroso Compounds....Pages 409-469 Heterocyclic-Amine Mutagens/Carcinogens in Foods....Pages 471-502 Modern Methods of DNA Adduct Determination....Pages 503-546 Biological Consequences of Reactions with DNA: Role of Specific Lesions....Pages 547-571 Back Matter....Pages 573-604 This handbook - the first of two complementary volumes - presents carcinogenesis and mutagenesis. To this end the subject matter covers theories behind the process of carcinogenesis, the ways in which such compounds are metabolized and interact with DNA and the detection and consequences of adduct formation. Relationships between mutagenesis and carcinogenesis are explored together with methods by which chemicals may be tested for mutagenic or carcinogenic properties and how these effects may be modified. Oncogenes and their activation are considered together with the mechanisms by which their role in carcinogenesis is effected. The volume is of broad interest to toxicologists and pharmacologists and of special appeal to graduate and post-graduate research workers studying carcinogenesis and mutagenesis. It is the first attempt to cover the entire range of carcinogenesis, from epidemiology to the effects of oncogenes on cellular differentiation, and contains excellent contributions from leading scientists. The handbook thus provides specialists in defined areas of cancer research with up-to-date overviews of adjacent areas