Chemical Biology : Approaches to Drug Discovery and Development to Targeting Disease

An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.Content: Chapter 1 The Role of Chemical Biology in Drug Discovery (pages 1–21): Andrew J. Pope Chapter 2 Computational Approaches to Drug Discovery and Development (pages 23–40): Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu and Hualiang Jiang Chapter 3 Design and Selection of Small Molecule Inhibitors (pages 41–63): Jianwei Che, Yi Liu and Nathanael S. Gray Chapter 4 Lead Optimization in Drug Discovery (pages 65–81): Craig W. Lindsley, David Weaver, Thomas M. Bridges and J. Phillip Kennedy Chapter 5 Pharmacokinetics of Drug Candidates (pages 83–100): Ronald E. White Chapter 6 ADME Properties of Drugs (pages 101–114): Li Di and Edward H. Kerns Chapter 7 Drug Transport in Living Systems (pages 115–132): Yael Elbaz and Shimon Schuldiner Chapter 8 Blood?Brain Barrier: Considerations in Drug Development and Delivery (pages 133–146): David S. Miller and Brian T. Hawkins Chapter 9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery (pages 147–164): Zhong Zuo and Vincent H. L. Lee Chapter 10 Pharmaceuticals: Natural Products and Natural Product Models (pages 165–201): Sheo B. Singh Chapter 11 The Role of Chemical Biology in Understanding and Treating Disease?Are Small Molecule “Correctors” the Way of the Future? (pages 1–214): David Selwood Chapter 12 Anxiety Disorders (pages 215–243): Miklos Toth Chapter 13 Chronic Obstructive Pulmonary Disease (COPD) (pages 245–265): Peter J. Barnes Chapter 14 Depression (pages 267–292): Glen B. Baker and Nicholas D. Mitchell Chapter 15 Osteoarthritis (pages 293–329): Marjolaine Gosset, Jeremie Sellam, Claire Jacques and Francis Berenbaum Chapter 16 Human Immunodeficiency Virus (HIV) (pages 331–339): Joseph P. Vacca Chapter 17 Allergy and Asthma (pages 341–355): Garry M. Walsh Chapter 18 Schizophrenia (pages 357–378): Ferenc Martenyi Chapter 19 Protein Misfolding and Disease (pages 379–400): Johanna C. Scheinost, Grant E. Boldt and Paul Wentworth Chapter 20 Protein Trafficking Diseases (pages 401–417): Heidi M. Sampson and David Y. Thomas Chapter 21 Metabolic Diseases (pages 419–443): Cynthia M. Arbeeny Chapter 22 Mitochondrial Medicine (pages 445–460): Richard J. T. Rodenburg and Jan A. M. Smeitink Chapter 23 Lysosomal Disorders (pages 461–481): Doug A. Brooks and Maria Fuller **__An authoritative look at the application of chemical biology in drug discovery and development__** Based on the award-winning __Wiley Encyclopedia of Chemical Biology__ published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the __Encyclopedia__ as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: * The design, development, and optimization of drug candidates * The pharmacokinetics and properties of drugs * Drug transport and delivery * Natural products and natural product models as pharmaceuticals * Biological mechanisms underlying health and disease * Treatment strategies for a range of diseases, from HIV to schizophrenia __Chemical Biology__ is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.Content: Chapter 1 The Role of Chemical Biology in Drug Discovery (pages 1–21): Andrew J. PopeChapter 2 Computational Approaches to Drug Discovery and Development (pages 23–40): Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu and Hualiang JiangChapter 3 Design and Selection of Small Molecule Inhibitors (pages 41–63): Jianwei Che, Yi Liu and Nathanael S. GrayChapter 4 Lead Optimization in Drug Discovery (pages 65–81): Craig W. Lindsley, David Weaver, Thomas M. Bridges and J. Phillip KennedyChapter 5 Pharmacokinetics of Drug Candidates (pages 83–100): Ronald E. WhiteChapter 6 ADME Properties of Drugs (pages 101–114): Li Di and Edward H. KernsChapter 7 Drug Transport in Living Systems (pages 115–132): Yael Elbaz and Shimon SchuldinerChapter 8 Blood?Brain Barrier: Considerations in Drug Development and Delivery (pages 133–146): David S. Miller and Brian T. HawkinsChapter 9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery (pages 147–164): Zhong Zuo and Vincent H. L. LeeChapter 10 Pharmaceuticals: Natural Products and Natural Product Models (pages 165–201): Sheo B. SinghChapter 11 The Role of Chemical Biology in Understanding and Treating Disease?Are Small Molecule “Correctors” the Way of the Future? (pages 1–214): David SelwoodChapter 12 Anxiety Disorders (pages 215–243): Miklos TothChapter 13 Chronic Obstructive Pulmonary Disease (COPD) (pages 245–265): Peter J. BarnesChapter 14 Depression (pages 267–292): Glen B. Baker and Nicholas D. MitchellChapter 15 Osteoarthritis (pages 293–329): Marjolaine Gosset, Jeremie Sellam, Claire Jacques and Francis BerenbaumChapter 16 Human Immunodeficiency Virus (HIV) (pages 331–339): Joseph P. VaccaChapter 17 Allergy and Asthma (pages 341–355): Garry M. WalshChapter 18 Schizophrenia (pages 357–378): Ferenc MartenyiChapter 19 Protein Misfolding and Disease (pages 379–400): Johanna C. Scheinost, Grant E. Boldt and Paul WentworthChapter 20 Protein Trafficking Diseases (pages 401–417): Heidi M. Sampson and David Y. ThomasChapter 21 Metabolic Diseases (pages 419–443): Cynthia M. ArbeenyChapter 22 Mitochondrial Medicine (pages 445–460): Richard J. T. Rodenburg and Jan A. M. SmeitinkChapter 23 Lysosomal Disorders (pages 461–481): Doug A. Brooks and Maria Fuller

An authoritative look at the application of chemical biology in drug discovery and development

Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases.

Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including:

• The design, development, and optimization of drug candidates
• The pharmacokinetics and properties of drugs
• Drug transport and delivery
• Natural products and natural product models as pharmaceuticals
• Biological mechanisms underlying health and disease
• Treatment strategies for a range of diseases, from HIV to schizophrenia

Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

"Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a fairly general overview of the role of chemical biology in drug discovery and development and in understanding biological mechanisms of common diseases"-- Provided by publisher