Chelation Therapy in the Treatment of Metal Intoxication

__Chelation Therapy in the Treatment of Metal Intoxication__ presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. __Chelation Therapy in the Treatment of Metal Intoxication__ describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). * Presents all the current findings on the potential for chelation as a therapy for metal intoxication * Presents practical guidelines for selecting the most appropriate chelating agent * Includes coverage on radionuclide exposure and metal storage diseases * Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system.

Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS).

• Presents all the current findings on the potential for chelation as a therapy for metal intoxication
• Presents practical guidelines for selecting the most appropriate chelating agent
• Includes coverage on radionuclide exposure and metal storage diseases
• Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D, L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds Content: Front matter,Copyright,Contributors,Preface,List of AbbreviationsEntitled to full textChapter 1 - General Chemistry of Metal Toxicity and Basis for Metal Complexation, Pages 1-33 Chapter 2 - Chelating Agents as Therapeutic Compounds—Basic Principles, Pages 35-61 Chapter 3 - Diagnosis and Evaluation of Metal Poisonings and Chelation Therapy, Pages 63-83 Chapter 4 - Chelation Treatment During Acute and Chronic Metal Overexposures—Experimental and Clinical Studies, Pages 85-252 Chapter 5 - Decorporation of Radionuclides, Pages 253-284 Chapter 6 - Chelating Therapy in Metal Storage Diseases, Pages 285-311 Chapter 7 - Guidance for Clinical Treatment of Metal Poisonings—Use and Misuse of Chelating Agents, Pages 313-341 Chapter 8 - Conclusions and Guidelines for Future Research, Pages 343-350 Subject Index, Pages 351-371