Chaperokine Activity of Heat Shock Proteins

Chaperokine, is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators like cytokines, chemokines, nitric oxide, apotogenic mediator, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity. The book **__Chaperokine Activity of Heat Shock Proteins__** provides the most comprehensive review on contemporary knowledge on the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide a synopsis of novel mechanisms, signal transduction pathways and how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain. To enhance the ease of reading and comprehension this book has been subdivided into various section, including; Section I, reviews current progress on our understanding of Immunological and Inflammatory Responses; Section II, evaluates the role of Physiological Responses and Section III, focuses the reader on the Therapeutic Approach. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts, Pathologists, Pharmaceutical Scientists and Researchers involved in Drug Discovery. Front Matter ....Pages i-ix Front Matter ....Pages 1-1 The Chaperokine Activity of Heat Shock Proteins (Punit Kaur, Alexzander A. A. Asea)....Pages 3-22 Extracellular HSP70, Neuroinflammation and Protection Against Viral Virulence (Michael Oglesbee, Mi Young Kim, Yaoling Shu, Sonia Longhi)....Pages 23-55 Biology of Extracellular HSP60 (Brice Nativel, Cynthia Planesse, Philippe Gasque, Christine Robert Da Silva, Olivier Meihac, Wildriss Viranaïcken)....Pages 57-80 Heat Shock Protein 60: A Mediator of Atherosclerosis and Its Potential Therapeutic Role (Cecilia Wick)....Pages 81-103 Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases (Hana Storkanova, Michal Tomcik)....Pages 105-121 Upregulation of Cytoprotective Chaperones Mediate Better Tolerance to High Altitude (Richa Rathor, Geetha Suryakumar)....Pages 123-145 Role of Chaperone Mediated Autophagy in Viral Infections (Hoorieh Soleimanjahi, Asghar Abdoli)....Pages 147-154 Chaperones in Sterile Inflammation and Injury (Asmita Choudhury, Pranoti Mandrekar)....Pages 155-177 Chaperone-Like Proteins in Inflammation and Immunomodulation: Examples of Resistin and PPIases (Saurabh Pandey, Javeed Ahmad, Nasreen Zafar Ehtesham)....Pages 179-191 Exercise-Induced Chaperokine Activity of Hsp70: Possible Role in Chronic Diseases (Mahdieh Molanouri Shamsi, Zuhair Mohammad Hassan, Reza Gharakhanlou)....Pages 193-209 Therapeutic Implications of Heat Shock Proteins in Cancer (Maxim Shevtsov, Gabriele Multhoff)....Pages 211-243 Front Matter ....Pages 245-245 Physical Exercise and Heat Shock Proteins (Amin Isanejad, Hamid Amini)....Pages 247-277 Extracellular Hsp90 Governs Spatio-Temporal Regulation of Biological Responses (Yasuaki Tamura, Akihiro Yoneda, Norio Takei, Kaori Sawada)....Pages 279-297 HSP47 and Its Involvement in Fibrotic Disorders (Haiyan Chu, Li Jin, Jiucun Wang)....Pages 299-312 Back Matter ....Pages 313-320 Chaperokine is a term that describes the unique function of extracellular heat shock protein (eHsp) as both chaperone and cytokine. The cellular consequence of binding and signaling of eHsp is the stimulation of a potent and long lasting immune response. eHsp induces a plethora of immune responses including the release of bioactive mediators such as cytokines, chemokines, nitric oxide, apotogenic mediators, stimulation of the innate and adaptive immune response, migration and maturation of dendritic cells (DC) and the enhancement of natural killer cell-mediated cellular cytotoxicity. This edited book provides the most comprehensive review of contemporary knowledge of the chaperokine activity of heat shock proteins (HSP) in biology and medicine. Using an integrative approach to understanding the chaperokine activity of HSP, the contributors provide an overview of novel mechanisms, signal transduction pathways and a concise understanding of how the principles of the chaperokine activity of HSP has been harnessed for therapeutic gain. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present cutting-edge research activities and importantly, the future direction of chaperokine research. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychology, Human Physiology, Zoology, Botany, Biotechnology, Molecular Medicine, Infectious Disease, Pathology and Pharmaceutical Sciences, as well as for researchers involved in Drug Discovery