Central Nervous System Diseases: Innovative Animal Models From Lab To Clinic (contemporary Neuroscience)

In Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic, prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases, as well as their advantages and limitations. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies. Front Matter....Pages i-xv Front Matter....Pages 1-1 The Cholinergic Hypothesis a Generation Later....Pages 3-45 Patterns of Cognitive Decline in the Aged Rhesus Monkey....Pages 47-64 Cholinergic Lesions as a Model of Alzheimer’s Disease....Pages 65-80 The Immunolesioned Animal as a Model of Transmitter Dysfunction....Pages 81-92 An Intracerebral Tumor Necrosis Factor-α Infusion Model for Inflammation in Alzheimer’s Disease....Pages 93-112 The Senescence-Accelerated Mouse as a Possible Animal Model of Senile Dementia....Pages 113-122 Transgenic Mice Overexpressing Presenilin cDNAs....Pages 123-128 Front Matter....Pages 129-129 Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism....Pages 131-151 Development of Behavioral Outcome Measures for Preclinical Parkinson’s Research....Pages 153-169 Behavioral Assessment in the Unilateral Dopamine-Depleted Marmoset....Pages 171-186 Molecules for Neuroprotection and Regeneration in Animal Models of Parkinson’s Disease....Pages 187-207 Antisense Knockdown of Dopamine Receptors....Pages 209-226 Is Trophic Factor Gene Disruption a “Knockout” Model for Parkinson’s Disease?....Pages 227-246 Front Matter....Pages 247-247 Operant Analysis of Striatal Dysfunction....Pages 249-273 Intrastriatal Injections of Quinolinic Acid as a Model for Developing Neuroprotective Strategies in Huntington’s Disease....Pages 275-299 Systemic Administration of 3-Nitropropionic Acid....Pages 301-332 Replicating Huntington Disease’s Phenotype in Nonhuman Primates....Pages 333-353 Transgenic Mouse Models of Huntington’s Disease....Pages 355-367 Front Matter....Pages 369-369 Rigid Indentation Models of Traumatic Brain Injury in the Rat....Pages 371-392 Rodent Ischemia Models of Embolism and Ligation of the Middle Cerebral Artery....Pages 393-406 Front Matter....Pages 369-369 A Primate Model of Hypertensive Cerebrovascular Disease....Pages 407-428 Front Matter....Pages 429-429 Nicotinic Therapeutics for Tourette Syndrome and Other Neuropsychiatric Disorders....Pages 431-440 Neural Grafting for Parkinson’s and Huntington’s Disease....Pages 441-483 Future Prospects of Gene Therapy for Treating CNS Diseases....Pages 485-508 Back Matter....Pages 509-512

Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.

The book contains black-and-white illustrations.

World-renowned neuroscientists present a broad review of the use of animal models for the study of major neurological diseases including Alzheimer’s, Parkinson’s, Huntington’s, and neurodegenerative disorders. The chapters cover the model systems utilized by the leading laboratories throughout the world and provide a detailed background for scientists wishing to employ new animal model studies in their neuroscience research. The final section of the book relates the models to actual preclinical and clinical results established in the field.