Central D1 Dopamine Receptors (advances In Experimental Medicine And Biology)

The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects. The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor is a molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor, proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transuding systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects. This volume is based on papers presented at the Symposium on Central D1 Dopamine Receptors held at the Chemist's Club in New York City on December 5, 1986. The editors would like to thank Dr. Frank Bullock of Schering Corporation and Dr. John Vogel Front Matter....Pages i-viii Dopamine-Regulated Protein Phosphorylation in the Basal Ganglia....Pages 1-17 The D-1 Dopamine Receptor....Pages 19-31 Biochemical Properties of D 1 and D 2 Dopamine Receptors....Pages 33-41 Biochemical and Functional Characterization of Central Dopamine Receptors....Pages 43-53 Dopamine D 1 and D 2 Receptor Selectivities of Agonists and Antagonists....Pages 55-63 DARPP-32 as a Marker for D-1 Dopaminoceptive Cells in the Rat Brain: Prenatal Development and Presence in Glial Elements (Tanycytes) in the Basal Hypothalamus....Pages 65-82 Studies on Central D1 Receptors Role in Volume Transmission, Neuroendocrine Regulation and Release of Noradrenaline....Pages 83-119 N-Ethoxycarbonyl-2-Ethoxy-1, 2-Dihydroquinoline (EEDQ): A New Tool to Probe CNS Receptor Function....Pages 121-136 Pharmacological and Behavioral Effects of D 1 Dopamine Antagonists....Pages 137-144 Neurophysiological Examination of the Role of D-1 Dopamine Receptors in the Regulation of Neuronal Activity in the Basal Ganglia....Pages 145-158 Diminished D 2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements....Pages 159-167 D-1 Dopamine Receptors and Arousal....Pages 169-178 Back Matter....Pages 179-183