Cellular Stress Responses in Renal Diseases (Contributions to Nephrology, Vol. 148)

Heat shock proteins are a distinctive class of proteins that have evolved to cope with stress and to provide cellular defense against a wide range of cell injuries. Cellular stress responses include a transient rearrangement of functional activities in order to protect and maintain essential cellular functions. The science of stress responses in various renal diseases is a new and still evolving medical discipline which offers the prospect of new alternate therapeutic options. This publication provides basic information about the important role of stress proteins in several renal diseases, ranging from hypoxic injuries to fibrotic renal disorders and tumors. Each chapter is written in a clear but concise style and includes illustrations necessary to highlight essential biological pathways which have been discovered during the past few years. Providing an overview of contemporary issues, this book will be a useful reference book for clinicians and basic researchers in the fields of cell biology, pathology and nephrology who are either involved in dealing with patients suffering from various renal diseases or in defining various stress responses during tissue injury and subsequent organ damage.

This collection of ten articles by international experts presents an overview of contemporary thoughts on the clinical significance of stress responses following renal injury, with chapters arranged to provide the reader significant and up-to-date information on the involvement of heat shock proteins (HSPs) in acute and chronic renal diseases. Article topics include an overview of the involvement of stress proteins in renal diseases and the relationship to glomerular epithelial cell injury, responses of renal medullary cells to osmotic stress, heat shock proteins in renal cell carcinomas, heat shock protein 47 and renal fibrogenesis, cytoprotective effects of heme oxygenase in acute renal failure, cisplatin-associated nephrotoxicity and pathological events, heat shock proteins and allograft rejection, and oxidant stress in renal pathophysiology. Annotation ©2005 Book News, Inc., Portland, OR

"This publication provides basic information about the important role of stress proteins in several renal diseases, ranging from hypoxic injuries to fibrotic renal disorders and tumors. Each chapter is written in a clear but concise style and includes illustrations necessary to highlight essential biological pathways which have been discovered during the past few years." "Providing an overview of contemporary issues, this volume will be a useful reference book for clinicians and basic researchers in the fields of cell biology, pathology and nephrology who are either involved in dealing with patients suffering from various renal diseases or in defining various stress responses during tissue injury and subsequent organ damage."--Jacket