Cellular Proteins and Their Fatty Acids in Health and Disease

In light of the increasing importance of these proteins and their ligands for our understanding of cellular growth, differentiation, and development, as well as of diseases such as obesity, insulin resistance, atherosclerosis, cancer, and inflammation, a team of internationally renowned editors and authors have compiled here the very first comprehensive book on these topics. They describe fatty acid-activated transcription factors as well as membrane and soluble fatty acid transporters, covering such aspects as structure and function, lipid-protein interaction, delivery of ligands, and the roles of these proteins in gene expression pertaining to the homeostatic and diseased states of cells and organs.Incorporating recent findings, this is indispensable for basic scientists, health professionals in industry and clinics as well as postgraduate students.Contributors among others: N.A. Abumrad, J.E. Schaffer, G. Schmitz, N.J. Brunskill, J. Storch, U. Seedorf, S. Mandrup, C.N.A. Palmer, T. Perlmann, H.I. Nebb, J. Bar-Tana, H. Kondo, C. Wolfrum, C. Kerkhoff , S. Farmer, E.J. Murphy, J.F.C. Glatz, P. Besnard, J.M. Stewart, A. Meirhaeghe, J. Plutzky, W. Wahli, R.A. Roberts In Light Of The Increasing Importance Of These Proteins And Their Ligands For Our Understanding Of Cellular Growth, Differentiation, And Development, As Well As Of Diseases Such As Obesity, Insulin Resistance, Atherosclerosis, Cancer, And Inflammation, A Team Of Internationally Renowned Editors And Authors Have Compiled Here The Very First Comprehensive Book On These Topics. They Describe Fatty Acid-activated Transcription Factors As Well As Membrane And Soluble Fatty Acid Transporters, Covering Such Aspects As Structure And Function, Lipid-protein Interaction, Delivery Of Ligands, And The Rol. Cellular Proteins And Their Fatty Acids In Health And Disease; Preface; Contents; List Of Contributors; Part 1 The Molecular Basis Of Protein-lipid Interaction And Functional Consequences; 1 Structure-function Of Cd36 And Evidence For Its Role In Facilitating Membrane Fatty Acid Transport; 2 Role And Function Of Fatps In Fatty Acid Uptake; 3 Function, Expression, And Regulation Of Human Abc Transporters; 4 Albumin Receptors -- Structure And Function; 5 Intracellular Lipid Binding Proteins: Evolution, Structure, And Ligand Binding; 6 Fatty Acid Binding Proteins And Fatty Acid Transport. Asim K. Duttaroy And Friedrich Spener (eds.). Includes Bibliographical References And Index. A book on the increasing importance of fatty acid-activated transcription factors, membrane-bound and soluble transporters for fatty acids in gene expression, development and such diseases as obesity, atherosclerosis, cancer and inflammation. CD36 (also known as GPIV, GPIIIb, PAS IV, and FAT) is an integral membrane glycoprotein with a wide cellular distribution.