Cellular Peptidases In Immune Functions And Diseases (advances In Experimental Medicine And Biology)

Membrane Peptidases in Immune Functions and Inflammation: Membrane Metalloendopeptidases in Immune Function and Disease; J.S. Bond, W. Jiang. Structural Studies of Aminopeptidase P: A Novel Cellular Peptidase; A.J. Turner, et al. Aminopeptidase P - A Cell-Surface Antigen of Endothelial and Lymphoid Cells; J. Lasch, et al. CD26/Dipeptidylpeptidase IV on Lymphocytes: Structure of CD26 (Dipeptidylpeptidase IV) and Function in Human T Cell Activiation; M. Hegen, et al. Molecular Associations Required for Signalling via Dipeptidylpeptidase IV (CD26); B. Fleischer, et al. CD26/Dipeptidylpeptidase IV in Lymphocyte Growth Regulation; S. Ansorge, et al. Peptidases Involved in Cytokine Actions and in the Pathogenesis of Disease: Regulation of Neurophil Activation by Proteolytic Processing of Platelet-Derived alpha-Chemokines; H.-D. Flad, et al. Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases; U. Bank, et al. In vitro Effects of gamma-Glutamyltranspeptidase Inhibitor Acivicin on Human Myeloid and B Lineage Cells; B. Bauvois. 32 additional articles. Index. Front Matter....Pages i-xii Membrane Metalloendopeptidases in Immune Function and Disease....Pages 1-6 Structural Studies of Aminopeptidase P....Pages 7-16 Aminopeptidase P....Pages 17-23 Human Lymphocyte X-Prolyl Aminopeptidase (Aminopeptidase P)-Like Protein....Pages 25-29 Specific Inhibitors of Aminopeptidase P....Pages 31-35 γ -Glutamyl Transpeptidase, a Blood-Brain Barrier Associated Membrane Protein....Pages 37-45 Structure and Expression of Aminopeptidase N....Pages 47-57 Activation-Dependent Induction of T Cell Alanyl Aminopeptidase and Its Possible Involvement in T Cell Growth....Pages 59-66 Antisense-Mediated Inhibition of Aminopeptidase N (CD13) Markedly Decreases Growth Rates of Hematopoietic Tumour Cells....Pages 67-73 Co-Incubation of Lymphocytes with Fibroblast-Like Synoviocytes and other Cell Types Can Induce Lymphocytic Surface Expression of Aminopeptidase N/CD13....Pages 75-79 Two Transfected Endothelial Cell Lines Expressing High Levels of Membrane Bound or Soluble Aminopeptidase N....Pages 81-84 Aminopeptidase N-Mediated Signal Transduction and Inhibition of Proliferation of Human Myeloid Cells....Pages 85-91 Regulation of Thymic Development by Neprilysin Inhibition....Pages 93-99 Proteases of Isolated Pancreatic Acinar Cells after Caerulein Hyperstimulation....Pages 101-108 Structure of CD26 (Dipeptidyl Peptidase IV) and Function in Human T Cell Activation....Pages 109-116 Molecular Associations Required for Signalling VIA Dipeptidyl Peptidase IV (CD26)....Pages 117-125 CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation....Pages 127-140 CD26 is Involved in Regulation of Cytokine Production in Natural Killer Cells....Pages 141-147 The Effect of Anti-CD26 Antibodies on DNA Synthesis and Cytokine Production (IL-2, IL-10 and IFN- γ ) Depends on Enzymatic Activity of DP IV/CD26....Pages 149-155 New Fluorogenic Dipeptidyl Peptidase IV/CD26 Substrates and Inhibitors....Pages 157-160 Molecular Analyses of Human and Rat Dipeptidyl Peptidase IV....Pages 161-169 A Molecular Model of the Active Site of Dipeptidyl Peptidase IV....Pages 171-178 The Level of CD26 Determines the Rate of HIV Entry in a CD4 + T-Cell Line....Pages 179-184 HIV-1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26....Pages 185-192 Further Characterization of DPP IV-β, a Novel Cell Surface Expressed Protein with Dipeptidyl Peptidase Activity....Pages 193-199 Expression of Dipeptidylpeptidase IV (DPP IV/CD26) Activity on Human Myeloid and B Lineage Cells, and Cell Growth Suppression by the Inhibition of DPP IV Activity....Pages 201-205 CD26 as a Positive Regulator of HIV Envelope-Glycoprotein Induced Apoptosis in CD4 + T Cells....Pages 207-216 Comparative Study of CD26 as a Th1-Like and CD30 as a Potential Th2-Like Operational Marker in Leprosy....Pages 217-221 Regulation of Neutrophil Activation by Proteolytic Processing of Platelet-Derived α-Chemokines....Pages 223-230 Selective Proteolytical Cleavage of the Ligand-Binding Chains of the IL-2-Receptor and IL-6-Receptor by Neutrophil-Derived Proteases....Pages 231-242 In Vitro Effects of γ -Glutamyltranspeptidase Inhibitor Acivicin on Human Myeloid and B Lineage Cells....Pages 243-246 Expression of Several Matrix Metalloproteinase Genes in Human Monocytic Cells....Pages 247-251 Lysosomal Cysteine Peptidases and Malignant Tumours....Pages 253-257 Expression of Cysteine Protease Inhibitors Stefin A, Stefin B, and Cystatin C in Human Lung Tumor Tissue....Pages 259-265 Contribution of the Proteasome to the α-Secretase Pathway in Alzheimer’s Disease....Pages 267-272 Dipeptidyl Peptidase IV (CD26) and Alzheimer Amyloid Protein Precursor (APP) in Polymyositis....Pages 273-277 The HIV Protease and Therapies for AIDS....Pages 279-284 Leukodiapedesis, Function, and Physiological Role of Leucocyte Matrix Metalloproteinases....Pages 285-301 Matrix Metalloproteinases in Experimental Autoimmune Encephalomyelitis....Pages 303-306 Interaction of Transforming Growth Factor ß (TGFß) with Proteinase 3....Pages 307-313 Liver Cysteine Proteinases in Macrophage Depression Induced by Gadolinium Chloride....Pages 315-321 Back Matter....Pages 323-338 **Membrane Peptidases in Immune Functions and Inflammation:**__J.S. Bond, W.__ Structural Studies of Aminopeptidase P: A Novel Cellular Peptidase; Aminopeptidase P - A Cell-Surface Antigen of Endothelial and Lymphoid Cells; __al.__ Structure of CD26 (Dipeptidylpeptidase IV) and Function in Human T Cell Activiation; __Hegen, et al.____B. Fleischer, et al.____S.__**Peptidases Involved in Cytokine Actions and in the** Regulation of Neurophil Activation by Proteolytic Processing of Platelet-Derived alpha-Chemokines; __Flad, et al.____U. Bank, et al.__ Effects of gamma-Glutamyltranspeptidase Inhibitor Acivicin on Human Myeloid and B Lineage Cells; 32 additional articles. Index.