Cellular Mechanisms of Alzheimer's Disease : Special Topic Issue: Neurodegenerative Diseases 2006, Vol. 3, No. 4-5

This special topic issue of 'Neurodegenerative Diseases' contains contributions discussing the subject in-depth. 'Neurodegenerative Diseases' is a well-respected, international peer-reviewed journal in 'Neurobiology'. Special topic issues are included in the subscription. Contents......Page 4 Preface......Page 6 Six Years of Collaborative Alzheimer’s Disease Research in Germany......Page 8 The Microtubule-Associated Protein Tau......Page 12 Primary Structure of Tau and Prediction of Folding......Page 13 Global Features of Unfolded Proteins......Page 15 Long-Range Structure in Tau......Page 16 (Un)folding and Aggregation......Page 17 Conclusions......Page 19 References......Page 20 Introduction......Page 22 Materials and Methods......Page 23 MARK......Page 24 MARKK......Page 25 Outlook:Modes of MARK Regulation......Page 28 References......Page 31 Subcellular Trafficking of APP/APLPs......Page 33 Pathogenic Role of the APP Gene Family in Axonal Transport......Page 38 References......Page 39 Introduction......Page 42 Presenilin Function in C.elegans......Page 43 Suppressors and Enhancers of Presenilin in C. elegans......Page 44 References......Page 46 Abstract......Page 48 References......Page 52 Introduction......Page 54 APP/APLP Loss of Function Studies......Page 55 Roles of APP/APLP Proteins in the Formation of Neuromuscular Synapses and in Cortical Development......Page 56 Acknowledgement......Page 59 References......Page 60 Trafficking and Proteolytic Processing of APP......Page 62 Role of Glycosphingolipids in the Subcellular Transport of APP and the Generation of Abeta......Page 64 Role of BACE1 and BACE2 in APP Processing......Page 65 Role of GGA Proteins in the Proteolytic Processing of betaAPP......Page 66 References......Page 67 Introduction......Page 70 Identification of ADAM10 as an alpha-Secretase......Page 71 Transcriptional Regulation of the Human alpha-Secretase ADAM10 Gene......Page 72 Activation of alpha-Secretase via G Protein-Coupled Receptors......Page 73 Concluding Remarks......Page 74 References......Page 75 Proteolytic Processing of APP......Page 77 Expression Cloning Screen for Modifiers of APP Shedding......Page 78 Specificity of Identified cDNAs for APP Shedding......Page 79 Control of APP Shedding by Modulators of General Endocytosis......Page 80 APLP1 Modulates APP Shedding......Page 81 Conclusion......Page 82 References......Page 83 Abstract......Page 85 References......Page 88 Introduction......Page 90 Identification of gamma-Secretase......Page 91 Localization of gamma-Secretase and Its Cellular Site(s) of Activity......Page 92 Assembly of the gamma-Secretase Complex......Page 94 Acknowledgments......Page 95 References......Page 96 Introduction......Page 99 SPP-Like Proteins......Page 100 Nicalin (Nicastrin-Like Protein)......Page 102 References......Page 103 BACE Inhibitors......Page 105 Gamma-Secretase Inhibitors......Page 108 Outlook......Page 111 References......Page 112 Introduction: Abeta42 as a Therapeutic Target in Alzheimer’s Disease......Page 113 Gamma-Secretase Inhibition versus gamma-Secretase Modulations......Page 114 Abeta42-Lowering Compounds: In vitro Studies and Mechanism of Action......Page 115 Preclinical in vivo Studies and Clinical Trials with Abeta42-Lowering Compounds......Page 117 Acknowledgement......Page 118 References......Page 119 APP Processing......Page 120 Lipids – Risk Factor for AD......Page 121 The Role of APP and PSs in vivo......Page 122 Statins and Abeta-Mediated Cholesterol Downregulation......Page 123 Acknowledgement......Page 124 References......Page 125 Subject Index......Page 127