Cellular and Molecular Basis of Mitochondrial Inheritance: Mitochondrial Disease and Fitness (Advances in Anatomy, Embryology and Cell Biology Book 231)

This new volume of our successful book series __Advances in Anatomy, Embryology and Cell Biology__ is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including __Drosophila,____C. elegans,__ bivalve molusc __Mytilus__ and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers. This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers. Front Matter ....Pages i-xi Autophagosomal Sperm Organelle Clearance and mtDNA Inheritance in C. elegans (Jorge Merlet, Karinna Rubio-Peña, Sara Al Rawi, Vincent Galy)....Pages 1-23 Doubly Uniparental Inheritance of mtDNA: An Unappreciated Defiance of a General Rule (Eleftherios Zouros, George C. Rodakis)....Pages 25-49 Exogenous Factors May Differentially Influence the Selective Costs of mtDNA Mutations (Wen C. Aw, Michael R. Garvin, J. William O. Ballard)....Pages 51-74 Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction (Kanokwan Srirattana, Justin C. St. John)....Pages 75-103 Mitochondria Inspire a Lifestyle (Peter Kramer, Paola Bressan)....Pages 105-126