Cellular and Biomolecular Mechanics and Mechanobiology (Studies in Mechanobiology, Tissue Engineering and Biomaterials, 4)

This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads. Front Matter....Pages i-ix Cytoskeletal Mechanics and Cellular Mechanotransduction: A Molecular Perspective....Pages 3-27 Forces During Cell Adhesion and Spreading: Implications for Cellular Homeostasis....Pages 29-69 The Physical Mechanical Processes that Shape Tissues in the Early Embryo....Pages 71-97 Mechanobiology of Primary Cilia....Pages 99-124 Mechanical Response of Living Cells to Contacting Shear Forces....Pages 125-141 Microfabricated Devices for Studying Cellular Biomechanics and Mechanobiology....Pages 145-175 Nanotechnology Usages for Cellular Adhesion and Traction Forces....Pages 177-200 The Mechanical Environment of Cells in Collagen Gel Models....Pages 201-245 Biomechanical Characterization of Single Chondrocytes....Pages 247-266 Mechanics of Airway Smooth Muscle Cells and the Response to Stretch....Pages 261-293 Biomechanical Modelling of Cells in Mechanoregulation....Pages 297-329 Finite Element Modeling of Cellular Mechanics Experiments....Pages 331-344 Multiscale Computation of Cytoskeletal Mechanics During Blebbing....Pages 345-371 Mechanobiology and Finite Element Analysis of Cellular Injury During Microbubble Flows....Pages 373-429 Mathematical Modelling of Cell Adhesion in Tissue Engineering using Continuum Models....Pages 431-450 Cell–Material Communication: Mechanosensing Modelling for Design in Tissue Engineering....Pages 451-462 Structure–Mechanical Property Changes in Nucleus arising from Breast Cancer....Pages 465-475 Adhesion and Signaling of Tumor Cells to Leukocytes and Endothelium in Cancer Metastasis....Pages 477-521 Cellular Mechanics of Acute Leukemia and Chemotherapy....Pages 523-558 Back Matter....Pages 559-560