Cell Transplantation For Neurological Disorders: Toward Reconstruction Of The Human Central Nervous System (contemporary Neuroscience)

In Cell Transplantation for Neurological Disorders, distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, stroke, and epilepsy. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included. Cell Transplantation for Neurological Disorders is the first major book on the clinical use of neural reconstruction techniques. Authoritative and comprehensive, the book reviews the field at a critical threshold, evaluating those variables that will become critical as the methodology and favorable outcomes mature. Booknews Provides a resource for clinicians working to establish a neural reconstruction program or working in an existing program, emphasizing clinical issues related to neural transplantation. Considers only those diseases which are likely to be amenable to transplant therapy within the next five years, including Parkinson's disease, Huntington's disease, demyelinating diseases, stroke, and pain. Coverage includes strategies using human fetal cells and the use of cross-species cell lines. Of interest to neurosurgeons, immunologists, and molecular and cell biologists. Includes b&w photos. Annotation c. by Book News, Inc., Portland, Or. Front Matter....Pages i-xviii The Lund Transplant Program for Parkinson’s Disease and Patients with MPTP-Induced Parkinsonism....Pages 1-17 Fetal Nigral Transplantation in Parkinson’s Disease....Pages 19-30 Toward a Phase III Multicenter Study of Fetal Ventral Mesencephalic Transplants in Patients with Late-Stage Parkinson’s Disease....Pages 31-43 PET Studies of Transplantation Therapy....Pages 45-50 Neuropathology of Dopaminergic Transplants in Patients with Parkinson’s Disease....Pages 51-75 Fetal-Tissue Transplantation for Huntington’s Disease: Preclinical Studies ....Pages 77-93 Fetal Transplantation for Huntington’s Disease: Clinical Studies ....Pages 95-134 Topographic Factors Affecting the Functional Viability of Dopamine-Rich Grafts in the Neostriatum....Pages 135-169 Immunological Issues in Rodent and Primate Transplants (Allografts)....Pages 171-187 Transplanting Fetal Neural Xenogeneic Cells in Parkinson’s and Huntington’s Disease Models....Pages 189-210 Animal Models of Cerebral Ischemia....Pages 211-230 Transplantation Strategies for the Treatment of Pain....Pages 231-251 Treatment of Central Nervous System Diseases with Polymer-Encapsulated Xenogeneic Cells....Pages 253-286 Transplant Strategies in Myelin Disorders....Pages 287-302 Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases....Pages 303-331 Adequately Respecting and Protecting Fetal Tissue Donors and Their Next-of-Kin....Pages 333-338 Back Matter....Pages 339-350 Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included. This text covers such topics as: somatotopic organization of the striatum and its relevance to neural transplantation; evaluation of patients with Parkinson's disease; the Lund Transplant Program (Parkinson's disease and MPTP patients); and the Paris Program.