Cell Therapy (Keio University International Symposia for Life Sciences and Medicine Book 5)

Modern cell biology has brought improvements in therapy for advanced malignant diseases through immunomodulation, hematopoietic stem cell transplantation, and other advanced techniques. Collected here are selected papers from the Fifth International Symposium of Keio University for Life Sciences and Medicine on Cell Therapy. All chapters include innovative basic research for clinical application: immunotherapy, cancer vaccination, molecular biology of hematopoietic stem cells, stem cell processing, and gene therapy. The book is divided into three parts: Immunotherapy for malignant diseases; Hematopoietic stem cell biology and clinical application; and International collaboration in hematopoietic stem cell transplantation. Included in the third part is information on bone marrow registries from around the world. The book thus presents up-to-date information on biological and clinical aspects of treatment, with insight into the future of cell therapy. The book contains black-and-white illustrations. Front Matter....Pages I-XVI Front Matter....Pages 1-1 Breaking Immunological Tolerance to Tumor Cells as a Novel Immunotherapy for Cancer....Pages 3-13 SART1 Gene Encoding Squamous Cell Carcinoma Antigen Recognized by Cytotoxic T Lymphocytes....Pages 15-28 Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones....Pages 29-44 Adoptive Transfer of Polyclonal, EBV-Specific Cytotoxic T-Cell Lines for the Prevention and Treatment of EBV-Associated Malignancies....Pages 45-60 Processing of Antigens by Dendritic Cells: Nature’s Adjuvant....Pages 61-68 Immunotherapy of Melanoma Using Dendritic Cells....Pages 69-76 Immunotherapy of Melanoma Using T-Cell-Defined Antigens....Pages 77-92 Front Matter....Pages 93-93 Isolation and Characterization of CD34-Low/Negative Mouse Hematopoietic Stem Cells....Pages 95-103 Ex Vivo Expansion of Human Hematopoietic Stem Cells....Pages 105-106 Notch in Hematopoiesis: Cell Fate Decisions and Self-Renewal of Progenitors....Pages 107-121 Molecular Genetics of Acute Promyelocytic Leukemia: A Rationale for “Transcription Therapy” for Cancer....Pages 123-132 A Novel Acute Promyelocytic Leukemia Model: From Cell to Murine System....Pages 133-142 Phase 1 Trial of Retroviral-Mediated Transfer of the Human MDR-1 in Patients Undergoing High-Dose Chemotherapy and Autologous Stem Cell Transplantation....Pages 143-157 Basic Studies Toward Hematopoietic Stem Cell Gene Therapy....Pages 159-169 Ex Vivo Expansion of Hematopoietic Cells....Pages 171-183 Harnessing Graft-Versus-Leukemia Without Myeloablative Therapy....Pages 185-193 Ex Vivo Expansion of Human Cord Blood Stem Cells and Genetic Manipulation....Pages 195-204 Front Matter....Pages 205-205 Unrelated Donor Stem Cell Transplantation: A Registry Perspective....Pages 207-208 European Bone Marrow Donor Registries: Collaboration and Individualism....Pages 209-221 Asian Bone Marrow Donor Registries: Their Roles in International Cooperation....Pages 223-223 Front Matter....Pages 205-205 Cord Blood Stem Cell Transplantation: Banking and Clinical Results....Pages 225-238 Back Matter....Pages 239-240