Cell Function and Disease

The new experimental tools and approaches of modern biology have allowed us to better understand many fundamental properties of the eukaryotic cells. These significant discoveries have drastically changed the diagnostic and therapeutic approaches of modern clinical practice. On April 18-22, 1988, an International Symposium on Cell Function and Disease was held in Monterrey, Nuevo Leon, Mexico, aimed at reviewing some of the most recent advances made in the following five areas: Genes and Human Diseases; Cellular and Molecular Pathology; Infectious Diseases; Brain Transplants and the New Approaches and Techniques with Potential Application to Cell Function and Disease. This book is based on the contributed papers of the symposium. To underline the importance of the clinical approach to the study of cell function and disease a section on this subject was added at the end of the book. The chapters in this volume include contributions by some of the leading scientists of the international scientific community and Mexico. During the course of this international conference, numerous discussions were held by the local and international representatives of the scientific community concerning the creation of an International Center of Molecular Medicine aimed at stimulating further interaction between molecular biologists, biochemists, biophyscists and clinicians. Such ideas received the endorsement and support of the Director General of the united Nations Educational and Scientific Organization (UNESCO), Federico Mayor, the Governor of the State of Nuevo Leon, Jorge Trevino, and the Secretary of Health of Mexico, Guillermo Soberon. Front Matter....Pages i-x Towards Active Chromatin Structure....Pages 1-6 Molecular Genetics Of Wilms’ Tumor....Pages 7-24 Mechanisms Of Altered Growth Regulation In Human Leukemia....Pages 25-31 The Human Placental Lactogen and Growth Hormone Multi-Gene Family....Pages 33-57 Overproduction of Proteins by Recombinant DNA: Human Insulin....Pages 59-74 Diagnosis And Characterization of New Mutations in Man....Pages 75-83 Clinical Aspects of Inborn Errors of Metabolism....Pages 85-88 Functional Components of Cell Membranes as the Locale of Pathological Phenomena....Pages 89-92 Molecular and Physiological Properties of Plasma Membranes: The Role of Ion Channels....Pages 93-107 Transmembrane Channels and Disease....Pages 109-114 Protein Kinase C: Structure, Function And Modulation Of Its Catalytic Activity By Physiological And Pharmacological Agents....Pages 115-132 The Signaling Function of Calcium and Its Regulation....Pages 133-143 pH Homeostasis and Cell Functions and Diseases....Pages 145-157 The “Cytosol”: A Neglected and Poorly Understood Compartment of Eukaryotic Cells....Pages 159-170 Molecular Basis Of Radioprotection By Aminothiols....Pages 171-188 Cytochrome P-450, P-448 And Lipid Peroxidation in Cell Damage....Pages 189-198 Oxygen is a Dangerous Friend....Pages 199-207 Free Radical Mechanisms in Tissue Injury....Pages 209-218 Human Uricase Loss: An Evolutionary Gain Against Disease....Pages 219-223 Recovery of Function After Tissue Transplantation in the Nigrostriatal Dopamine System....Pages 225-234 Nerve Growth Factor in Vivo Actions on Cholinergic Neurons in the Adult Rat CNS....Pages 235-248 Strategies For Improving Fetal Neuronal Integration with Adult Brain Following Brain Transplantation....Pages 249-260 Fetal Brain Transplants Induce Recovery of Morphological and Learning Deficits of Cortical Lesioned Rats....Pages 261-274 Oral Vaccination of Human Volunteers With galE Mutants of Enteropathogenic Escherichia coli....Pages 275-280 The Role of Outer Membrane Proteins From Gram-Negative Bacteria as VACCINES with Special Emphasis in Typhoid Fever: Monoclonal antibodies against S. typhi porins....Pages 281-292 Structural and Functional Modifications of Plasmodium-Infected Erythrocytes....Pages 293-307 Inflammatory Response in Amebic Liver Abscess....Pages 309-324 Biological Determinants of Host-Parasite Relationship in Mouse Cysticer-Cosis Caused by Taenia crassiceps : Influence of Sex, Major Histocompatibility Complex and Vaccination....Pages 325-332 Detection of the Human Papillomavirus Genome in Cervical Cancer....Pages 333-341 Population Dynamics Of Aids: Basic Concepts....Pages 343-353 Structure-Based Targeting of Drugs to HIV Proteins....Pages 355-362 On the Development of New Chemotherapeutic Agents in the Coming Decade....Pages 363-376 Investigation Of Metabolic Disorders in Patients and Animal Models Using Magnetic Resonance Spectroscopy....Pages 377-392 Electrorotation of Blood Cells: Medical Applications....Pages 393-398 Molecular Dysfunctions in Lead Poisoning: An In Vitro Model....Pages 399-403 Molecular Basis of Contrast in MRI....Pages 405-413 Disease Detection By MR Imaging: T1 And T2 Relaxation Times....Pages 415-420 Magnetic Resonance Relaxation Times and Imaging in the Pathophysiology of Muscles....Pages 421-443 Magnetic Resonance Imaging (MRI) of the Pituitary Gland in Sheehan’s Syndrome....Pages 445-455 Cancer Detection by Magnetic Resonance Imaging....Pages 457-465 Treatment Evaluation of Amebic Liver Abscess by MR Imaging....Pages 467-475 Planning the Clinical Research Protocol to Understand the Relationship Between Cell Function and Disease....Pages 477-509 Back Matter....Pages 511-524