Cell Cycle Inhibitors in Cancer Therapy: Current Strategies (Cancer Drug Discovery and Development)

leading Clinicians And Investigators Review In A Comprehensible And User-friendly Style All The Latest Information About The Molecular Biology Of Cell Cycle Control And Demonstrate Its Clinical Relevance To Understanding Neoplastic Diseases. Topics Range From Cdk Inhibitors And Cell Cycle Regulators To The Prognostic Value Of P27 And Tumor Suppressor Genes As Diagnostic Tools. Actual Case Studies Show How The New Molecular Understanding Has Produced Such Drugs As Flavopiridol And Sulindac. The Book Brings All The Recent Critical Research Findings To Bear On Clinical Practice, And Clearly Shows Their Powerful Impact On The Diagnostics, Prognostics, And Therapeutics Of Cancer, Aids, And Cardiovascular Disease. 1: Cdk Inhibitors - Background and Introduction......Page 1 2: p27, A Prognostic Indicator Reflecting ...?......Page 11 3: Cell Cycle Control of Transcription at the G1/S Phase Transition......Page 31 4: Tumor-Suppressor Genes as Diagnostic Tools......Page 49 5: Regulation of Cell Cycle and Apoptosis......Page 83 6: CDK Inhibitors as Targets of Chemoprevention Agents......Page 119 7: Cell Cycle Regulatory Genes as Targets of Retinoids......Page 145 8: Modulators of Cyclin-Dependent Kinases - A Novel Therapeutic Approach for the Treatment of Neoplastic Diseases......Page 179 9: Cell Cycle Regulators - Interactions and Their Role in Diagnosis, Prognosis, and Treatment of Cancer......Page 207 10: Cell Cycle Regulators as Targets of Anticancer Therapy......Page 253 11: Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer......Page 277 12: Synthetic Oligopeptides as Cancer Cell Cycle Modulators......Page 297 Index......Page 311 Back......Page 327