Cell Cycle Inhibitors In Cancer Therapy: Current Strategies (cancer Drug Discovery And Development)

The molecular approach to disease continues to yield a tremendous amount of new information about those aspects of cellular replication that we use to understand, prevent, diagnose, and cure cancer. In Cell Cycle Inhibitors in Cancer Therapy: Current Strategies, recognized clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell-cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor-suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. Up-to-date and richly instructive, Cell Cycle Inhibitors in Cancer Therapy: Current Strategies brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease. Front Matter....Pages i-x Cdk Inhibitors....Pages 1-10 p27, A Prognostic Indicator Reflecting ...?....Pages 11-29 Cell Cycle Control of Transcription at the G1/S Phase Transition....Pages 31-48 Tumor-Suppressor Genes as Diagnostic Tools....Pages 49-82 Regulation of Cell Cycle and Apoptosis....Pages 83-118 CDK Inhibitors as Targets of Chemoprevention Agents....Pages 119-143 Cell Cycle Regulatory Genes as Targets of Retinoids....Pages 145-177 Modulators of Cyclin-Dependent Kinases....Pages 179-205 Cell Cycle Regulators....Pages 207-252 Cell Cycle Regulators as Targets of Anticancer Therapy....Pages 253-275 Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer....Pages 277-296 Synthetic Oligopeptides as Cancer Cell Cycle Modulators....Pages 297-310 Back Matter....Pages 311-326

Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.