Cell Biology of Herpes Viruses (Advances in Anatomy, Embryology and Cell Biology Book 223)

Herpes viruses are widely distributed in nature, causing disease in organisms as diverse as bivalves and primates, including humans. Each virus appears to have established a long-standing relationship with its host, and the viruses have the ability to manipulate and control the metabolism of host cells, as well as innate and adaptive antiviral immune responses. Herpes viruses maintain themselves within hosts in a latent state resulting in virus persistence for years – usually for the life span of the hosts. Herpes viruses comprise a large number of pathogens with diverse cellular targets and biological consequences of infection. What they have in common is their structure and the fact that they establish a dormant (latent) infection in their hosts that usually persists for life. The reviews here will highlight the general principles of herpes virus infection, with equal attention to overall principle and important difference. Also, the cell type- and life-style dependent differences in the establishment and maintenance of virus persistence will be covered. Front Matter....Pages i-vii Initial Contact: The First Steps in Herpesvirus Entry....Pages 1-27 Herpes simplex virus Membrane Fusion....Pages 29-47 Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease....Pages 49-75 The Human CMV IE1 Protein: An Offender of PML Nuclear Bodies....Pages 77-94 Herpesvirus Latency: On the Importance of Positioning Oneself....Pages 95-117 Herpesvirus Capsid Assembly and DNA Packaging....Pages 119-142 Herpesvirus Nuclear Egress....Pages 143-169 Assembly and Egress of an Alphaherpesvirus Clockwork....Pages 171-193 Interindividual Spread of Herpesviruses....Pages 195-224