Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease (Volume 36) (Advances in Molecular and Cell Biology, Volume 36)

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin. Content: Chapter 1 Lipid Rafts and Caveolae Organization Review Article Pages 1-36 Friedhelm Schroeder, Barbara P. Atshaves, Adalberto M. Gallegos, Avery L. McIntosh, J. C. Steve Liu, Ann B. Kier, Huan Huang, Judith M. Ball Chapter 2 Caveolae and the Regulation of Cellular Cholesterol Homeostasis Review Article Pages 37-55 William V. Everson, Eric J. Smart Chapter 3 The Caveolae Internalization Machinery Review Article Pages 57-77 L.S. Orlichenko, M.A. McNiven* Chapter 4 Lipid Raft-Mediated Entry of Bacteria into Host Cells Review Article Pages 79-88 Matthew J. Duncan, Soman N. Abraham Chapter 5 The Caveolin Interaction with Endothelial Nitric Oxide Synthase (eNOS) Review Article Pages 89-108 Olivier Feron Chapter 6 Caveolae and Estrogen Receptor Signaling Review Article Pages 109-123 Philip W. Shaul, Ken L. Chambliss Chapter 7 eNOS Regulation by Sphingosine 1-Phosphate and Caveolin Review Article Pages 125-140 Junsuke Igarashi Chapter 8 Insulin Signaling and Caveolae Review Article Pages 141-169 Peter Strålfors Chapter 9 Caveolin-3, Caveolae, and Hereditary Muscle Diseases Review Article Pages 171-186 Matthias Vorgerd Chapter 10 Caveolae and Caveolins in the Vascular System: Functional Roles in Endothelia, Macrophages, and Smooth Muscle Cells Review Article Pages 187-209 Ghada S. Hassan, Michael P. Lisanti, Philippe G. Frank Chapter 11 Caveolin Proteins in Cardiopulmonary Disease and Lung Cancers Review Article Pages 211-233 Jean-François Jasmin, Philippe G. Frank, Michael P. Lisanti Contributors Pages ix-xi Preface Pages xiii-xv Abbreviations and Acronyms Pages 235-236 Index Pages 237-245 Contents Pages v-viii "Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathways. As a consequence, they may play a key role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects."--BOOK JACKET The advent and almost universal acceptance of the Singer fluid-mosaic model over 30 years ago (Singer and Nicolson, 1972) led to the concept that membrane lipids spontaneously form a bilayer structure composed of randomly assembled lipids wherein proteins are inserted. The first book available dedicated to caveolae in human diseases and cellular metabolism