Catecholamines and the Heart : Recent Advances in Experimental and Clinical Research

An International Symposium "Catecholamines and the Heart" was held in Munich in May 1981, which was organized in cooperation with the Council on Cardiac Metabolism of the International Society and Federation of Cardiology and with the Microcirculation Working Group of the European Society of Cardiology. It was the aim of the organizers to evaluate in this Symposium the recent advances made in the field of sympathetic control of heart function. Particular attention was given to neural sympathetic pathways, to mechanisms and consequences of adrenoceptor stimulation and blockade as well as to clinically relevant implications mainly regarding the significance of catecholamines and of adrenoceptors in various heart diseases. The broad scope was covered in 34 papers presented by physiologists, pharmacologists and cardiologists during a two day meeting which was attended by an international audience. This book includes all papers as well as the discussions following each presentation. To accomplish rapid publication the manuscripts are published as submitted by the authors. The discussions were edited making use of the written questions and answers of the discussants. The Symposium was generously sponsored by Astra Chemicals GmbH, Wedell Holstein, Germany, which thus made possible a very fruitful exchange of information, ideas and concepts between specialists in various disciplines. The organizers gratefully acknowledge this support once again and would like to thank Dr. T. Kreuzer, the representative of Astra Chemicals, for his personal engagement. Front Matter....Pages I-XIX Front Matter....Pages IN1-IN1 Regulation of Sympathetic Outflow to the Heart....Pages 1-10 Relationship Between Sympathetic Outflow to Muscles, Heart Rate and Plasma Noradrenaline in Man....Pages 11-18 Classification and Function of Adrenoceptors....Pages 19-28 Role of Presynaptic and Postsynaptic Adrenoceptors in Cardiac Function....Pages 29-38 Sympathetic Control of Coronary Circulation....Pages 39-52 Identification of Cardiac Alpha-Adrenergic Receptors by Direct Binding Studies: Clinical Implications....Pages 53-60 Identification and Characterization of Beta-Adrenergic Receptors in Myocardium Under Normal and Pathologic Conditions....Pages 61-71 Catecholamines and β-Adrenergic Receptors in the Non-ischemic Myocardium After Coronary Occlusion....Pages 72-91 Heart Catecholamines in Genetic Hypertension....Pages 92-106 Front Matter....Pages IN2-IN2 Principles of Signal Transformations Mediated by Subtypes of Adrenergic Receptors....Pages 107-117 Occurrence and Functional Significance of Cardiac Muscle Protein Kinases....Pages 118-127 Cyclic AMP-Dependent Activation of Protein Kinases in the Myocardium....Pages 128-141 Antiadrenergic Action sof Adenosine in the Heart: Possible Physiological Significance....Pages 142-153 Effects of Ionic Composition on Cardiac Sarcolemmal Adenylate Cyclase....Pages 154-158 Catecholamines and Cardiac Adenine Nucleotide Metabolism....Pages 159-169 Beta-Adrenoceptor Stimulation and Membrane Calcium Permeability....Pages 170-176 The Problem of Catecholamine Oxygen Wasting in the Heart....Pages 177-183 Effects of Adrenergic Stimulation and Inhibition on Infarcting Myocardium....Pages 184-200 Catecholamines in Myocardial Hypoxia and Ischemia....Pages 201-209 Front Matter....Pages 210-210 Myocardial Catecholamines and Biosynthetic Enzymes in Various Heart Diseases of Man....Pages 211-222 Front Matter....Pages 210-210 Catecholamines in Patients with Coronary Heart Disease....Pages 223-235 Catecholamines in Patients with Heart Failure....Pages 236-246 Lymphocyte Beta-Adrenoreceptor Function in Congestive Heart Failure: Modulation by Dopamine-beta-Hydroxylase....Pages 247-256 Provoked Coronary Arterial Spasm....Pages 257-268 Catecholamines and Early Post-Infarction Arrhythmias: The Effects of α- and β-Adrenoceptor Blockade....Pages 269-284 Different Types of Beta-Blocking Agents: Therapeutic Implications....Pages 285-288 Myocardial Infarction and Beta-Adrenoceptor Blockade....Pages 289-303 The Role of Beta-Adrenoceptor Blockade in Congestive Cardiomyopathy....Pages 304-312 Comparison of Withdrawal Phenomena After Propranolol, Metoprolol and Pindolol....Pages 313-324 Sympathomimetic Drugs in the Treatment of Congestive Heart Failure....Pages 325-337 Effect of Vasodilator Therapy on Sympathetic Activity in Patients with Impaired Left Ventricular Function....Pages 338-344 Betablockers and Calcium Antagonists: Mode of Action in Angina pectoris....Pages 345-362 Beta-Blockers and Calcium Antagonists: Synergistic Effects....Pages 363-370 Beta-Blockers and Calcium Antagonists in Hypertrophic Obstructive Cardiomyopathy....Pages 371-378 Back Matter....Pages 379-386