Catalysis for Fine Chemical Synthesis. V.3. Metal Catalysed Carbon-Carbon Bond-Forming Reactions

Roberts S.M. et al. (eds. ) Wiley, 2004. — 282 p. Considerations of Industrial Fine Chemical Synthesis Alkylation and Allylation Adjacent to a Carbonyl Group Asymmetric Alkylation or Amination of Allylic Esters Suzuki Coupling Reactions Heck Coupling Reactions Sonogashira Coupling Reactions Cross-Coupling Reactions Regioselective or Asymmetric 1,2-Addition to Aldehydes Olefin Metathesis Reactions Cyclisation Reactions Asymmetric Aldol and Michael Reactions Stereoselective Hydroformylation, Carbonylation and Carboxylation Reactions Index

Catalysts for Fine Chemical Synthesis

Series Editors: Eric Derouane (Universidade do Algarve, Faro, and Instituto Superior Tecnico, Lisbon, Portugal)

Ivan V. Kozhevnikov (University of Liverpool, UK)

Stanley M Roberts (University of Manchester, UK)

Catalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there is a huge choice of high-tech catalysts that adds enormously to the repertoire of synthetic possibilities. However, catalysts are occasionally capricious, sometimes difficult to use and almost always require both skill and experience in order to achieve optimal results. This series offers practical help for advanced undergraduate, graduate and postgraduate students, as well as experienced chemists in industry and academia working with catalysts in organic and organometallic synthesis. It features tested and validated procedures, authoritative reviews on classes of catalysts, and assessments of all types of catalysts.

Catalysts for Fine Chemical Synthesis, Volume 5: Regio- and Stereo-Controlled Oxidations and Reductions

Editors: Stanley M. Roberts and John Whittall, (University of Manchester, UK)

Volume 5 in the series Catalysts for Fine Chemical Synthesis describes new procedures for the regio- and stereo-controlled transformations of compounds involving oxidation or reduction reactions. A wide range of catalysts are described, including organometallic systems, biocatalysts and biomimetics. Conversions that are discussed include:

• asymmetric hydrogenation of alkenes, enones, ene-esters and ene-acids

• asymmetric reduction of ketones

• imine reduction and reductive amination

• oxidation of primary and secondary alcohols

• hydroxylation, epoxidation and related reactions

• oxidation of ketones to lactones or enones

• oxidative C-C coupling

• oxidation of sulfides and sulfoxides

Regio- and Stereo-Controlled Oxidations and Reductions is a “how-to” practical guide with protocols detailed by the authors who have discovered the new transformations. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) are given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology are given and relevant references to the primary literature are cited. In order to put the different procedures into proper context, the editors provide a short overview of recent developments in the field of oxidations and reductions.

This book is an important text for practising synthetic organic chemists in industry and academia.

Catalysts Are Increasingly Used By Chemists Engaged In Fine Chemical Synthesis Within Both Industry And Academia. Today, There Exists A Huge Choice Of High-tech Catalysts, Which Add Enormously To The Repertoire Of Synthetic Possibilities. However, Catalysts Are Occasionally Capricious, Sometimes Difficult To Use And Almost Always Require Both Skill And Experience In Order To Achieve Optimal Results. This Series Aims To Be A Practical Help For Advanced Undergraduate, Graduate And Postgraduate Students, As Well As Experienced Chemists In Industry And Academia Working In Organic And Organometalli. Preface -- List Of Contributors -- Emergent Properties Of Biological Molecules And Cells R. P. J. Williams -- From Nineteenth Century Ideas On Reduction In Physiology To Non-reductive Explanations In Twentieth Century Biochemistry C. Debru -- Pitfalls Of Reductionism In Immunology M. H. V. Van Regenmortel -- Reductionism In Medicine: Social Aspects Of Health E. Lloyd -- 'who's Afraid Of Reductionism?' 'i Am!' S. Shostak -- Round Table Discussion 1 Chair: A. Rosenberg -- Reductionism In A Historical Science A. Rosenberg -- Varieties Of Reductionism: Derivation And Gene Selection D. L. Hull -- Gene: Between Holism And Reductionism M. Morange -- Genes Versus Molecules: How To, And How Not To, Be A Reductionist S. Sarak -- Limits On Reproduction: A Reductionist Research Strategy In Evolutionary Biology J. Griesemer -- Evolutionary Psychology: A Case Study In The Poverty Of Genetic Determinism J. Dupre -- Round Table Discussion 2 Chair: Marc Van Regenmortel -- Ethical Imperative Of Holism In Medicine A. Tauber -- Levels Of Explanation In Human Behaviour: The Poverty Of Evolutionary Psychology S. P. R. Rose -- Reductionism And Social Policy D. Nelkin -- Reductionism, Complexity And Molecular Medicine: Genetic Chips And The 'globalization' Of The Genome K. Schaffner -- Round Table Discussion Chair: K. Schaffner -- Index. Edited By Stan M. Roberts And Geraldine Poignant. Includes Bibliographical References And Index.

catalysts Are Increasingly Used By Chemists Engaged In Fine Chemical Synthesis Within Both Industry And Academia. Today, There Is A Huge Choice Of High-tech Catalysts That Adds Enormously To The Repertoire Of Synthetic Possibilities. However, Catalysts Are Occasionally Capricious, Sometimes Difficult To Use And Almost Always Require Both Skill And Experience In Order To Achieve Optimal Results. This Series Offers Practical Help For Advanced Undergraduate, Graduate And Postgraduate Students, As Well As Experienced Chemists In Industry And Academia Working With Catalysts In Organic And Organometallic Synthesis. It Features Tested And Validated Procedures, Authoritative Reviews On Classes Of Catalysts, And Assessments Of All Types Of Catalysts.
micro- And Mesoporous Solid Catalysts Describes The Use Of Zeolites And Mesoporous Solids As Catalysts For The Production Of Fine And Specialty Chemicals. Specific Tips And Hints Are Provided And Some Typical Procedures Are Described In Detail. In Addition To Discussing The Pros And Cons Of Various Micro- And Mesoporous Solids Used As Catalysts, Several Major Organic Transformations Are Examined Including Aromatic Substitutions, Heterocyclic Ring Formation, Amines Synthesis, Oligomerisation, Oxidation And Hydroxylation, And Other Regioselective And Stereoselective Reactions.

micro- And Mesoporous Solid Catalysts Features Tutorial Introductory Chapters, Including Tips And Hints For Achieving Successful Organic Transformations. Important Reactions Are Featured Together With Recommendations To Resolve Potential Problems.

This Book Is An Important Text For Undergraduate And Graduate Students, Andprofessionals Working As Practising Zeolite And Synthetic Organic Chemists In Industry And Academia.

Catalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech catalysts, which add enormously to the repertoire of synthetic possibilities. However, catalysts are occasionally capricious, sometimes difficult to use and almost always require both skill and experience in order to achieve optimal results. This series aims to be a practical help for advanced undergraduate, graduate and postgraduate students, as well as experienced chemists in industry and academia working in organic and organometallic synthesis.

The series features:

* Tested and validated procedures.

* Authoritative reviews on classes of catalysts.

* Assessments of all types of catalysts.

* Expertise from the Leverhulme Centre for Innovative Catalysis, Liverpool, UK.

Arguably, catalysis by polyoxometalates has been one of the most successful areas in fundamental and applied catalysis in the last few decades. Industry is using these catalysts for a number of large-scale chemical processes. On the other hand, the enormous versatility of polyoxometalates offers significant opportunities for clean synthesis of fine and speciality chemicals. Much research is focussed on the use of these catalysts in laboratory scale synthesis.

The second volume in the series presents a survey of recent developments in catalysis by polyoxometalates for fine chemicals synthesis. One chapter concentrates on the practical preparation of specific acid and oxidation catalysts. Other chapters describe in detail the use in homogeneous and heterogeneous syntheses.

Catalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech catalysts, which add enormously to the repertoire of synthetic possibilities. However, catalysts are occasionally capricious, sometimes difficult to use and almost always require both skill and experience in order to achieve optimal results. This series aims to be a practical help for advanced undergraduate, graduate and postgraduate students, as well as experienced chemists in industry and academia working in organic and organometallic synthesis. The series features: • Tested and validated procedures. • Authoritative reviews on classes of catalysts. • Assessments of all types of catalysts. • Expertise from the Leverhulme Centre for Innovative Catalysis, Liverpool, UK. The review section in the first volume of the series contains a report by Stanley M. Roberts on the integration of biotransformations into the catalyst portfolio. The procedure section contains a wide variety of synthetic protocols, such as epoxidations of unsaturated ketones and esters, asymmetric reductions of carbon-oxygen double bonds, asymmetric hydrogenations of carbon-carbon double bonds and other types of reaction. The featured catalysts include a wide range of different materials such as poly-D-leucine, D-fructose-based dioxiranes, oxaborolidine borane, some important titanium and ruthenium complexes as well as baker's yeast. For each reaction there are one or several detailed protocols on how to prepare and employ the various catalysts. Volume 5 in the Catalysts for Fine Chemical Synthesis series describes new procedures for the regio- and stereo-controlled transformations of compounds involving oxidation or reduction reactions. It describes a wide range of catalysts, including organometallic systems, biocatalysts and biomimetics. This volume also includes descriptions of a variety of conversions, including: Baeyer-Villiger oxidations; Epoxidation reactions; Hydroxylation reactions; Oxidation of alcohols to aldehydes, ketones and carboxylic acids; Reduction of ketones; and Reduction of alkenes including α, β-unsaturated carbonyl compounds. The book will be an important text for practising synthetic organic chemists in industry and academia. Protocols are written in a standard format by the authors who have discovered them Hints, tips and safety advice (where appropriate) is given to ensure that the procedures are reproducible Indications are given as to the range of starting materials used and, where appropriate, comparisons to alternative methodology Includes relevant references to the primary literature. "Volume 5 in the series Catalysts for Fine Chemical Synthesis describes new procedures for the regio- and stereo-controlled transformations of compounds involving oxidation or reduction reactions. A wide range of catalysts are described, including organometallic systems, biocatalysts and biomimetics." "Regio- and Stereo-Controlled Oxidations and Reductions is a "how-to" practical guide with protocols detailed by the authors who have discovered the new transformations. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) are given to ensure, as far as possible, that the procedures are reproducible."--Jacket Polyoxometalates belong to a large class of nanosized metal-oxygen cluster anions.