Cardiovascular Genomics: New Pathophysiological Concepts: Proceedings of the 2001 European Science Foundation Workshop in Maastricht (Developments in Cardiovascular Medicine, 242)

Four years ago-in December 1997-the first European Science Foundation Workshop on Cardiovascular Specific Gene Expression was held in Maastricht. It was hardly possible to imagine the progress in the field in those four years. In 1997, gene expression was still an art focused on individual genes; in 200 I, many labs have access to micro-array facilities to determine the expression of thousands of genes simultaneously. In 1997, gene expression was an area of fundamental research in basis molecular biology laboratories; in 200 I, clinical cardiovascular research has incorporated gene expression approaches. In 1997, the interpretation of a gene expression experiment was usually straightforward; in 200 I, advanced bioinformatics tools are needed to approach the extreme complexities of genetic control of cell and tissue function. The second symposium in this series is focused on Cardiovascular Genomics. New Pathophysiological Concepts. The organizing committee chose to invite a group of renown scientists and young investigators around four topics of eminent importance in cardiovascular research. These topics reflect the major present-day clinical cardiovascular problems: atherosclerosis, hypertension, arrhythmias and heart failure. In addition to these four disease-driven topics, the workshop has sessions on gene expression methodologies and cellular transplant approaches to cardiovascular disease. Front Matter....Pages i-xix Genomics and Clinical Cardiology: Hype or Hope?....Pages 1-4 Front Matter....Pages 5-5 Salt-Sensitive Hypertension....Pages 7-19 Cardiovascular Proteomics: Effect of Hypoxic Conditions....Pages 21-28 Using Comparative Genome Analysis to Find Interaction Partners for Frataxin....Pages 29-40 Front Matter....Pages 41-41 In Vitro-In Vivo Gene Expression Analysis in Atherosclerosis....Pages 43-52 Front Matter....Pages 53-53 Human Essential Hypertension: Role of the Genes of the Renin-Aldosterone System....Pages 55-63 Gene Therapy for Hypertension: Future or Fiction?....Pages 65-75 Hormones and Signalling Pathways....Pages 77-81 Endothelial Changes in Hypertension....Pages 83-94 Front Matter....Pages 95-95 Towards Elucidation of Genetic Pathways in Cardiac Hypertrophy: Technique to Develop Microarrays....Pages 97-105 Gene Expression in Cardiac Hypertrophy and Failure: Role of G Protein-Coupled Receptors....Pages 107-114 Little Mice with Big Hearts: Finding the Molecular Basis for Dilated Cardiomyopathy....Pages 115-129 Cardiac Hypertrophic Signaling the Good, the Bad and the Ugly....Pages 131-156 Front Matter....Pages 157-157 Ion Channel Regulation: From Arrhythmias to Genes to Channels (to Cures?)....Pages 159-165 Differential Expression and Functional Regulation of Delayed Rectifier Channels....Pages 167-185 Genetic Polymorphisms and Their Role in Ventricular Arrhythmias....Pages 187-198 Molecular Mechanisms of Remodeling in Human Atrial Fibrillation....Pages 199-212 G-Protein β3-Subunit Polymorphism and Atrial Fibrillation....Pages 213-222 Front Matter....Pages 223-223 Human Stem Cell Gene Therapy....Pages 225-230 Towards Human Embryonic Stem Cell Derived Cardiomyocytes....Pages 231-243 Front Matter....Pages 223-223 Use of Mesenchymal Stem Cells for Regeneration of Cardiomyocytes and its Application to the Treatment of Congestive Heart Failure....Pages 245-255 Cellular Cardiac Reinforcement....Pages 257-264 Adducin Paradigm: An Approach to the Complexity of Hypertension Genetics....Pages 265-271 Back Matter....Pages 273-275 This volume will combine state-of-the-art chapters on the latest technical advances in combination with applications in the different fields of cardiovascular medicine, including atherosclerosis, hypertension, cardiac hypertrophy and failure and arrhythmias. In addition, the latest developments with respect to stem cell applications in cardiology will be addressed, including cell source selection, manipulation and applications